Table 1 Effects of LY379196 on ED50 values of chemotherapeutic drugs.
From: A protein kinase Cβ inhibitor attenuates multidrug resistance of neuroblastoma cells
Doxorubicin | Etoposide | Paclitaxel | Vincristine | Carboplatin | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
IMR-32 | (nM) | (nM) | (nM) | (nM) | (nM) | |||||
LY379196 | A | B | A | B | A | B | A | B | A | B |
0 nM | 6.3 | 110 | 1.7 | 0.51 | 760 | |||||
20 nM | 5.5 | 5.3 | 101 | 118 | 1.6 | 1.7 | 0.47 | 0.57 | 780 | 740 |
100 nM | 5.5 | 4.7 | 88 | 98 | 1.4 | 1.6 | 0.40 | 0.47 | 880 | 720 |
500 nM | 6.1 | 2.8 | 103 | 78 | 1.6 | 1.0 | 0.37 | 0.30 | 880 | 380 |
SH-SY5Y | (nM) | (nM) | (nM) | (nM) | (μM) | |||||
LY379196 | A | B | A | B | A | B | A | B | A | B |
0 nM | 9.3 | 109 | 8.3 | 1.41 | 1.9 | |||||
20 nM | 8.2 | 9.8 | 93 | 114 | 7.3 | 8.0 | 1.20 | 1.45 | 2.2 | 2.3 |
100 nM | 7.2 | 6.7 | 74 | 81 | 4.8 | 4.3 | 0.82 | 0.89 | 2.1 | 1.8 |
500 nM | 5.0 | 2.0 | 75 | 55 | 4.3 | 2.7 | 0.57 | 0.33 | 2.0 | 0.7 |
SK-N-BE(2) | (nM) | (μM) | (nM) | (nM) | (μM) | |||||
LY379196 | A | B | A | B | A | B | A | B | A | B |
0 nM | 920 | 7.2 | 117 | 42 | >100 | |||||
20 nM | 650 | 690 | 6.4 | 6.6 | 108 | 109 | 32 | 33 | >100 | >100 |
100 nM | 450 | 380 | 5.3 | 4.8 | 105 | 94 | 21 | 21 | >100 | >100 |
500 nM | 270 | 160 | 3.9 | 2.8 | 40 | 27 | 5.2 | 3.9 | >100 | >100 |