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Figure 1 | BMC Cancer

Figure 1

From: Expression of stabilized β-catenin in differentiated neurons of transgenic mice does not result in tumor formation

Figure 1

S37F mutant β-catenin activity in medulloblastoma DAOY cells. Cotransfection of the TOPLASH Wnt reporter and FLAG-tagged S37F mutant β-catenin into DAOY cells results in 41-fold higher luciferase activity than transfection of TOPFLASH alone. Similar transfections of wild-type β-catenin result in 3.8-fold higher luciferase activity. No luciferase activity was detected in cells transfected with pBluescript (Negative Control). (pTF – TOPFLASH plasmid; WT – wild-type).

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BMC Cancer

ISSN: 1471-2407

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