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Table 2 Toxicity parameters (104 cycles in 25 patients).

From: Raltitrexed (Tomudex) administration in patients with relapsed metastatic colorectal cancer after weekly irinotecan/5-Fluorouracil/Leucovorin chemotherapy

Parameter Grade (WHO) Per Cycle Percentage (%)
Neutropenia 1–2 54/104 52%
  3–4 29/104 28%
Anemia (Hg>3 gr/dl) 1–2 37/104 36%
Diarrhea 1–2 32/104 31%
  3 26/104 25%
Nausea-Vomiting 1–2 33/104 32%
Mucositis 1–2 14/104 13.5%
Per Patient
Fatigue 1–2 11/25 44%
Transaminases (ALT/AST) 1–2 3/25 12%
Worsening PS   6/25 24%