Figure 7
From: Adenoviral gene transfer of angiostatic ATF-BPTI inhibits tumour growth
Tumour response after systemic treatment with a single iv dose of 1010iu of the various vectors. The vectors employed are: Ad Adapt mhATF-BPTI (open circles), Ad Adapt hEndostatin (open squares), Ad Adapt mhATF (open triangles), and Ad Adapt empty (closed squares). 10 animals per group, vertical lines indicate SD. The arrow indicates the time of treatment. A: L44 tumours treated by Ad Adapt mhAB (p < 0.0001, ANOVA), Ad Adapt mhATF (p = 0.03, ANOVA), and Ad Adapt hEndo treatment (p = 0.007, ANOVA). The treatment began at day 20 when the tumours were 8 × 8 × 8 × m. B: Kaplan-Meyer plots of treated rats: end point tumour volume 20,000 mm3 (for the Ad Adapt mhAB, p < 0.0001, rank test). C: L42 tumour growth curves, the viruses were injected on day 14 when the tumours were 4 × 4 × 4 mm.