Table 3 Enriched gene networks downregulated via FoxO during cancer cachexia

x

x

x

x

x

collagen, type I, alpha 2

Col1a2

−4.26

−2.31

x

x

x

x

x

collagen, type I, alpha 1

Col1a1

−5.20

−2.44

x

x

x

x

x

collagen, type VI, alpha 1

Col6a1

−2.64

−1.70

x

x

x

x

x

collagen, type VI, alpha 2

Col6a2

−2.69

−1.71

x

x

x

x

x

collagen, type VI, alpha 3

Col6a3

−3.55

−1.75

x

x

x

thrombospondin 2

Thbs2

−1.62

−1.07

x

x

x

tenascin C (hexabrachion)

Tnc

−2.43

−1.45

x

x

integrin, beta 6

Itgb6

−10.24

−2.20

x

x

cartilage oligomeric matrix protein

Comp

−2.48

−1.05

x

x

chondroadherin

Chad

−16.34

−2.40

x

fibrillin 1

Fbn1

−2.86

−1.71

x

Rho-associated, coiled-coil protein kinase2

Rock2

−1.98

−1.16

x

x

collagen, type XIV, alpha 1 (undulin)

Col14a1

−2.08

−1.26

x

x

procollagen C-endopeptidase enhancer

Pcolce

−1.81

−1.10

x

matrix metallopeptidase 15

Mmp15

−3.12

−2.06

DAVID annotation

1

2

3

4

5

x

x

x

myozenin 3

Myoz3

−5.53

−1.99

x

x

x

integrin beta 1 binding protein 2 (melusin)

Itgb1bp2

−4.25

−2.07

x

x

x

junctophilin 2

Jph2

−3.95

−2.10

x

x

x

synemin, intermediate filament protein

Synm

−2.61

−1.47

x

x

x

homer homologue 1

Homer1

−2.26

−1.45

x

x

x

LIM domain binding 3/Zasp/Cypher

Ldb3

−1.84

−1.14

x

x

fibromodulin

Fmod

−3.29

−1.29

x

x

keratocan

Kera

−14.38

−3.30

x

x

lumican

Lum

−2.47

−1.43