SC-III3 markedly inhibited tumor growth in vivo. Mice were intraperitoneally injected with 2.5, 5 and 10 mg/kg of SC-III3 once a day for 14 days. Control was treated with normal vehicle, and positive control was intraperitoneally injected with 2.5 mg/kg of doxorubicin. (A) Resected tumor images from the experimental. (B) Tumor volume was measured every 3 days. (C) Tumor mass were weighed. (D) Nude mice weight was recorded once a day. Data were presented as Mean ± SEM, n = 10. The difference were significant at *p < 0.05, **p < 0.01 vs. control.