Table 2 Relationship between SIRT1 expression and the clinicopathological features of 99 patients with primary hepatocellular carcinoma
Factor | Category | Total No. of patients | SIRT1 negative (n = 23) | SIRT1 positive (n = 76) | P |
|---|---|---|---|---|---|
Age (years) | >50 | 44 | 8 (34.8) | 36 (47.4) | 0.287 |
|  | ≤50 | 55 | 15 (65.2) | 40 (52.6) |  |
Gender | Male | 89 | 22 (95.7) | 67 (88.2) | 0.296 |
| Â | Female | 10 | 1 (4.3) | 9 (11.8) | Â |
Size of tumor (cm)* | >5 | 44 | 6 (26.1) | 38 (50.0) | 0.043 |
|  | ≤5 | 55 | 17 (73.9) | 38 (50.0) |  |
Tumor number* | Single | 68 | 20 (87.0) | 48 (63.2) | 0.031 |
| Â | Multiple | 31 | 3 (13.0) | 28 (36.8) | Â |
TBIL (ÎĽmol/L) | >20 | 23 | 4 (17.4) | 19 (25.0) | 0.449 |
|  | ≤20 | 76 | 19 (82.6) | 57 (75.0) |  |
HBsAg | Positive | 96 | 22 (95.7) | 74 (97.4) | 0.674 |
| Â | Negative | 3 | 1 (4.3) | 2 (2.6) | Â |
AFP (ng/ml) | >400 | 40 | 7 (30.4) | 33 (44.6) | 0.228 |
|  | ≤400 | 57 | 16 (69.6) | 41 (55.4) |  |
Liver cirrhosis | Absent | 35 | 9 (39.1) | 26 (34.2) | 0.665 |
| Â | Present | 64 | 14 (60.9) | 50 (65.8) | Â |
TNM* | I | 47 | 17 (73.9) | 30 (39.5) | 0.038 |
| Â | II | 18 | 2 (8.7) | 16 (21.1) | Â |
| Â | III | 16 | 2 (8.7) | 14 (18.4) | Â |
| Â | IV | 18 | 2 (8.7) | 16 (21.1) | Â |