Prognostic impact of urokinase-type plasminogen activator system components in clear cell renal cell carcinoma patients without distant metastasis

Table 5 Association of the combination of uPA system component levels in tumour tissue specimens with disease-specific survival (DSS) and overall survival (OS) in the subgroup of ccRCC patients with organ-confined tumours (tumour stage pT1+2, n = 87) assessed by multivariate Cox’s regression analysis

Factor	No. cases	Disease-specific survival HR (95% CI) ^a	P	Overall survival HR (95% CI) ^a	P
uPA/uPAR ^b
uPA and uPAR low	35	1		1
uPA and/or uPAR high	52	9.83 (1.21-79.6)	0.032	1.03 (0.45-2.37)	0.942
uPA/PAI-1 ^b
uPA and PAI-1 low	37	1		1
uPA and/or PAI-1 high	50	3.23 (0.79-13.1)	0.101	1.30 (0.56-3.02)	0.541
uPAR/PAI-1 ^b
uPAR and PAI-1 low	35	1		1
uPAR and/or PAI-1 high	52	2.68 (0.67-10.8)	0.164	1.39 (0.58-3.29)	0.460

^aHR: hazard ratio; 95% CI: 95% confidence interval of multivariate Cox’s regression analysis; combinations of uPA system factors were separately added to the base model consisting of gender, age and tumour grade.
^bDichotomised into groups with high and low levels of uPA system factors by the medians.

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