Table 6 Current and recent perioperative gene and vaccine therapy trials for MIBC*

Uppsala University

Gene

Phase 1/IIa Intravesical instillation of AdCD40L that may improve anti-tumor immune response. Cystectomy followed phase 1 trial.

Completed. 8 patients with limited complications. Successful gene transfer detected in biopsies [33].

NCT00891748

Celldex Therapeutics

Vaccine

Phase II neoadjuvant and adjuvant administration of CDX-1307 vaccine with chemotherapy for bladder tumors expressing B-HCG protein for patients undergoing radical cystectomy.

Terminated due to lack of enrollment.

NCT01094496

MSKCC and NCI

Vaccine

Phase 1 adjuvant administration of NY-ESO-1 peptide vaccine with BCG + sargramostim for tumors expressing NY-ESO-1 or LAGE-1 antigens. Patients previously underwent radical cystectomy.

Competed. Results unreported.

NCT00070070