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Table 1 Current and recent perioperative clinical trial systematic searches for MIBC*

From: Current and recent clinical trials for perioperative systemic therapy for muscle invasive bladder cancer: a systematic review

Search category

Database

Search equation used

Trials selected/reviewed

Broad overview of all published abstracts

MEDLINE

(“bladder cancer” OR “urothelial cancer” OR “urothelial cell carcinoma” OR “transitional cell carcinoma”) AND (“bladder resection” OR “radical cystectomy”) AND (“perioperative chemotherapy” OR “adjuvant chemotherapy” OR “neoadjuvant chemotherapy” OR “targeted therapy” OR “biologic” OR “immunotherapy” OR “gene” OR “vaccine” )

744 abstracts reviewed^

All registered clinical trials with the NIH

Clinical trials registry

bladder cancer

25/695#

Trials of neoadjuvant chemotherapy

MEDLINE

((neoadjuvant) AND (chemotherapy OR cisplatin OR gemcitabine OR carboplatin OR methotrexate OR vinblastine OR doxorubicin OR adriamycin OR paclitaxel OR ifosfamide OR abraxane)) AND (bladder cancer) AND (radical cystectomy)

5/187

Trials of adjuvant chemotherapy

MEDLINE

((adjuvant) AND (chemotherapy OR cisplatin OR gemcitabine OR carboplatin OR methotrexate OR vinblastine OR doxorubicin OR adriamycin OR paclitaxel OR ifosfamide OR abraxane)) AND (bladder cancer) AND (radical cystectomy)

5/259

Trials of EGFR inhibitors

MEDLINE

(egfr inhibitor OR cetuximab OR erlotinib OR gefitinib OR genistein OR her-2 inhibitor OR lapatinib OR MGAH22 OR panitumumab OR trastuzumab) AND (bladder cancer OR radical cystectomy)

1/89

Trials of VEGF inhibitors

MEDLINE

(vegf inhibitor OR bevacizumab OR ramucirumab OR trebananib OR ziv aflibercept) AND (bladder cancer OR radical cystectomy)

0/64

Trials of other Tyrosine Kinase inhibitors

MEDLINE

(tyrosine kinase inhibitor OR dasatinib OR pazopanib OR sorafenib OR sunitinib) AND (bladder cancer OR radical cystectomy)

1/106

Trials of mTOR inhibitors

MEDLINE

(mTOR inhibitor OR everolimus OR sirolimus OR temsirolimus OR rapamycin) AND (bladder cancer OR radical cystectomy)

0/84

Trials of immune therapy

MEDLINE

(Immune therapy OR interferon-alpha) AND (bladder cancer OR radical cystectomy) AND (phase)

1/45

Trials of gene and vaccine therapy

MEDLINE

(vaccine OR gene therapy) AND (bladder cancer OR radical cystectomy) AND (phase)

1/87

  1. NIH = National Institute of Health.
  2. MEDLINE = Medical Literature Analysis and Retrieval System Online.
  3. *MEDLINE clinical trial abstracts were only reviewed dating from January 2009 to January 2014. Trials from the Clinical Trials Registry Online and the MEDLINE broad overview of the literature had no date restrictions.
  4. ^No trials were individually selected from the MEDLINE broad overview of the literature. Treatment classes and specific drugs were taken from this MEDLINE search and from the trials search of the Clinical Trials Registry to develop the systematic search equations for each individual treatment class.
  5. #This result includes phase III perioperative chemotherapy trials, phase II targeted therapy trials, and clinical trials of all phases for mTOR inhibitors, immune therapy, and gene and vaccine therapy.
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BMC Cancer

ISSN: 1471-2407

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