Table 1 Genotypes of seven SNPs in CYP3A5 , ABCB1 and ABCG2
From: Sunitinib-induced severe toxicities in a Japanese patient with the ABCG2 421 AA genotype
Gene | SNP | Allele | Amino acid | Genotype |
|---|---|---|---|---|
CYP3A5 | rs776746 | 6986A > G | Splice Site | AG |
ABCB1 | rs1128503 | 1236C > T | G412G | CT |
ABCB1 | rs2032582 | 2677G > T/A | A893S/T | GT |
ABCB1 | rs1045642 | 3435C > T | I1145I | CT |
ABCG2 | rs2231137 | 34G > A | V12M | GG |
ABCG2 | rs72552713 | 376G > A | Q126X | GG |
ABCG2 | rs2231142 | 421C > A | Q141K | AA |