Figure 3
From: ADAMTS2 gene dysregulation in T/myeloid mixed phenotype acute leukemia
FISH analysis and breakpoints identification. (A) FISH cohybridization with BAC clones RP11-641 M21 (specific for the ADAMTS2 gene) and RP11-990 K12 (specific for the TRD locus), identifying chromosomes 5 and 14 breakpoints, respectively. (B) The break in BAC RP11-641 M21 maps in the region included between exon 3 and 4 of the ADAMTS2 gene (red arrow); exons 1–3 encode for the propeptide domain of the ADAMTS2 protein.