Figure 1
From: Fenofibrate induces apoptosis of triple-negative breast cancer cells via activation of NF-κB pathway
Fenofibrate inhibits breast cancer cells proliferation. (A) Fenofibrate was able to inhibit the proliferation of twelve breast cancer cell lines in a dose-dependent manner, but had the least effect on MCF-10A cells. (B) The 72 h IC50 for each cell line was shown and the first five most sensitive cell lines to fenofibrate were all TNBC cell lines, that were MDA-MB-231, MDA-MB-453, BT549, MDA-MB-436 and MDA-MB-231HM cells, and MDA-MB-231 cells were the most sensitive ones. Data represent the means ± SD of three independent experiments. TNBC = triple-negative breast cancer. (C) A considerable number of MDA-MB-231 cells had morphological changes, including the shrinkage and rounding up of cells when treated with fenofibate.