Skip to main content

Table 2 Immunohistochemical results of MMPs and TIMPs in each subtype

From: Expression of matrix metalloproteinases and their inhibitors in different immunohistochemical-based molecular subtypes of breast cancer

Characteristics

Tumor subtype

Pvalue*

Luminal A (n = 123)

Basal-like (n = 31)

HER2 (n = 17)

Posistive No/Cases (%)

Positive No/Cases (%)

Positive No/Cases (%)

MMP 1

    

 Tumoral

13/123 (10.6)

3/31 (9.7)

2/17 (11.8)

1.000

 Stromal

96/123 (78.0)

22/31 (71.0)

13/17 (76.5)

0.470

MMP 2

    

 Tumoral

47/123 (38.2)

11/31 (35.5)

7/17 (41.2)

0.935

 Stromal

4/123 (3.3)

2/31 (6.5)

0/17 (0)

0.641

MMP 7

    

 Tumoral

100/123 (81.3)

31/31 (100)

12/17 (70.6)

0.005

 Stromal

35/123 (28.5)

11/31 (35.5)

5/17 (29.4)

0.767

MMP 9

    

 Tumoral

28/123 (22.7)

11/31 (35.5)

12/17 (70.6)

0.000

 Stromal

6/123 (4.9)

0/31 (0)

0/17 (0)

0.507

MMP 11

    

 Tumoral

115/123 (93.5)

30/31 (96.8)

17/17 (100)

1.000

 Stromal

101/123 (82.1)

29/31 (93.5)

13/17 (76.5)

0.253

MMP 13

    

 Tumoral

45/123 (36.6)

17/31 (54.8)

12/17 (70.6)

0.016

 Stromal

9/123 (7.32)

5/31 (16.1)

5/17 (29.4)

0.016

MMP 14

    

 Tumoral

67/123 (54.5)

21/31 (67.7)

12/17 (70.6)

0.331

 Stromal

42/123 (34.1)

5/31 (16.1)

5/17 (29.4)

0.118

TIMP 1

    

 Tumoral

64/122 (52.5)

12/31 (38.7)

10/17 (58.8)

0.274

 Stromal

22/122 (18.0)

4/31 (12.9)

2/17 (11.8)

0.748

TIMP 2

    

 Tumoral

62/123 (50.4)

16/31 (51.6)

11/17 (64.7)

0.657

 Stromal

16/123 (13.0)

6/31 (19.4)

4/17 (23.5)

0.368

TIMP 3

    

 Tumoral

100/123 (81.3)

27/31 (87.1)

16/17 (94.1)

0.605

 Stromal

45/123 (36.6)

18/31 (58.1)

8/17 (47.1)

0.107

  1. * P value obtained using the exact chi-square test.