Figure 1

Large-scale RNAi screen identifies PRKDC as a MYC synthetic lethal gene. Heat map of relative counts of 18 shRNAs for WI-38 cell lines stably-expressing empty vector (pCDH), L-MYC1 or L-MYC2, after infection with a pooled kinase shRNA library. Blue = high expression, red = low expression; intensity of color represents relative counts per million total reads. Highlighted in green (CDK2 and GSK3B) are previously published synthetic lethal partners of MYC.