Figure 4

PLS-DA score and loading plots of HER-2 ^neg versus HER-2 ^pos status in (A) ER ^neg , (B) ER ^pos , (C) PgR ^neg , and (D) PgR ^pos tumors. The score plots show the first and second latent variables (LV). In the loading plot, VIP scores are illustrated by heat map. The majority of HER-2^neg tumors show positive score for LV1, while most HER-2^pos tumors show negative score for LV1. HER-2^pos tumors contain higher Glycine level compared to HER-2^neg tumors. LV: latent variable, Gly: Glycine. PC: Phosphocholine.