Ranking the five studied doublets for tumor response and hematological AEs in 1691 included patients. a. Early treatment discontinuation. b. Treatment failure. c. Any hematological AE. d. Leukopenia. e. Anemia. f. Neutropenia. g. Thrombocytopenia. Abbreviations: AE, adverse event; OR, odds ratio; G-CSF, granulocyte colony-stimulating factor; EPO, erythropoietin; IL-11, interleukin 11; ECOG, Eastern Cooperative Oncology Group; TPO, thrombopoietin. Note: Only baseline variables with significant OR and the studied doublets were displayed in graphs.