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Table 1 Risk of SPC a by gender, age, year of first cancer diagnosis and follow-up, France 1989–2004 (N = 289,967)

From: The effect of patient characteristics on second primary cancer risk in France

   O E PYR SIR (95% CI) EARb (95% CI)
All patients 21,226 15,555.59 1,440,960 1.36 (1.35-1.38) 39.4 (37.4-41.3)
Gender Male 14,555 10,514.87 689,115 1.38 (1.36-1.41) 58.6 (55.2-62.1)
  Female 6,671 5,040.73 751,845 1.32 (1.29-1.36) 21.7 (19.6-23.8)
Age at first cancer diagnosis ≤ 44 y 909 424.88 210,515 2.14 (2.00-2.28) 23.0 (20.2-25.9)
45 y-54 y 2,592 1,270.67 236,678 2.04 (1.96-2.12) 55.8 (51.7-60.1)
55 y-64 y 5,284 3,500.56 334,536 1.51 (1.47-1.55) 53.3 (49.1-57.6)
65 y-74 y 7,772 6,235.67 406,356 1.25 (1.22-1.27) 37.8 (33.6-42.1)
≥ 75 4,669 4,123.81 252,874 1.13 (1.10-1.17) 21.6 (16.3-26.9)
Year of first cancer diagnosis 1989-1994 7,512 5,406.49 517,048 1.39 (1.36-1.42) 40.7 (37.5-44.0)
1995-1999 7,679 5,634.00 520,856 1.36 (1.33-1.39) 39.3 (36.0-42.6)
2000-2004 6,035 4,515.10 403,057 1.34 (1.30-1.37) 37.7 (34.0-41.5)
Follow-up ≥ 2 m- < 1 y 3,170 2,280.81 213,502 1.39 (1.34-1.44) 41.6 (36.5-46.9)
  ≥ 1 y- < 2 y 3,034 2,229.98 210,970 1.36 (1.31-1.41) 38.1 (33.0-43.3)
  ≥ 2 y- < 4 y 4,983 3,665.14 343,730 1.36 (1.32-1.40) 38.3 (34.3-42.4)
  ≥ 4 y- < 6 y 3,504 2,614.81 241,999 1.34 (1.30-1.39) 36.7 (32.0-41.6)
  ≥ 6 y- < 8 y 2,522 1,815.96 166,357 1.39 (1.34-1.44) 42.4 (36.6-48.5)
  ≥ 8 y- < 10 y 1,664 1,239.15 112,267 1.34 (1.28-1.41) 37.8 (30.8-45.1)
  ≥ 10 y 2,349 1,709.75 152,135 1.37 (1.32-1.43) 42.0 (35.8-48.4)
  1. SPC, second primary cancer; O, Observed; E, Expected; PYR, person-years at risk; SIR, standardized incidence ratio; EAR, excess absolute risk; CI, confidence interval; m, months; y, years.
  2. aExcluding SPC occurring in the same subsite as the first primary cancer.
  3. bNumber of excess cancers per 10,000 person-years at risk.