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Table 1 Risk of SPC a by gender, age, year of first cancer diagnosis and follow-up, France 1989–2004 (N = 289,967)

From: The effect of patient characteristics on second primary cancer risk in France

  

O

E

PYR

SIR

(95% CI)

EARb

(95% CI)

All patients

21,226

15,555.59

1,440,960

1.36

(1.35-1.38)

39.4

(37.4-41.3)

Gender

Male

14,555

10,514.87

689,115

1.38

(1.36-1.41)

58.6

(55.2-62.1)

 

Female

6,671

5,040.73

751,845

1.32

(1.29-1.36)

21.7

(19.6-23.8)

Age at first cancer diagnosis

≤ 44 y

909

424.88

210,515

2.14

(2.00-2.28)

23.0

(20.2-25.9)

45 y-54 y

2,592

1,270.67

236,678

2.04

(1.96-2.12)

55.8

(51.7-60.1)

55 y-64 y

5,284

3,500.56

334,536

1.51

(1.47-1.55)

53.3

(49.1-57.6)

65 y-74 y

7,772

6,235.67

406,356

1.25

(1.22-1.27)

37.8

(33.6-42.1)

≥ 75

4,669

4,123.81

252,874

1.13

(1.10-1.17)

21.6

(16.3-26.9)

Year of first cancer diagnosis

1989-1994

7,512

5,406.49

517,048

1.39

(1.36-1.42)

40.7

(37.5-44.0)

1995-1999

7,679

5,634.00

520,856

1.36

(1.33-1.39)

39.3

(36.0-42.6)

2000-2004

6,035

4,515.10

403,057

1.34

(1.30-1.37)

37.7

(34.0-41.5)

Follow-up

≥ 2 m- < 1 y

3,170

2,280.81

213,502

1.39

(1.34-1.44)

41.6

(36.5-46.9)

 

≥ 1 y- < 2 y

3,034

2,229.98

210,970

1.36

(1.31-1.41)

38.1

(33.0-43.3)

 

≥ 2 y- < 4 y

4,983

3,665.14

343,730

1.36

(1.32-1.40)

38.3

(34.3-42.4)

 

≥ 4 y- < 6 y

3,504

2,614.81

241,999

1.34

(1.30-1.39)

36.7

(32.0-41.6)

 

≥ 6 y- < 8 y

2,522

1,815.96

166,357

1.39

(1.34-1.44)

42.4

(36.6-48.5)

 

≥ 8 y- < 10 y

1,664

1,239.15

112,267

1.34

(1.28-1.41)

37.8

(30.8-45.1)

 

≥ 10 y

2,349

1,709.75

152,135

1.37

(1.32-1.43)

42.0

(35.8-48.4)

  1. SPC, second primary cancer; O, Observed; E, Expected; PYR, person-years at risk; SIR, standardized incidence ratio; EAR, excess absolute risk; CI, confidence interval; m, months; y, years.
  2. aExcluding SPC occurring in the same subsite as the first primary cancer.
  3. bNumber of excess cancers per 10,000 person-years at risk.