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Figure 6 | BMC Cancer

Figure 6

From: Unraveling the chromosome 17 patterns of FISH in interphase nuclei: an in-depth analysis of the HER2amplicon and chromosome 17 centromere by karyotyping, FISH and M-FISH in breast cancer cells

Figure 6

Representative FISH images of the MCF7, BT474, MDA-MB361 and SKBR3 breast cancer cell lines using HER2 /CEP17, STARD3 /CEP17 and TOP2A /CEP17 dual-color probes. Metaphase spreads are shown and boxes indicate representative interphase nuclei for each case. FISH images for the BT474, MDA-MB361 and SKBR3 cells demonstrated HER2 and STARD3 gene amplification, while TOP2A gene amplification was observed in the SKBR3 cells only. Gene signals are red-labeled, CEP17 signals are green-labeled.

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BMC Cancer

ISSN: 1471-2407

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