Table 1 Genomic coordinates, sizes and carrier frequencies of the studied deletion alleles
From: Recurrent CYP2C19 deletion allele is associated with triple-negative breast cancer
Disrupted gene | Location of deletion | Deletion size | Carrier frequency, n/N (%) | P-value | OR (95% CI) | |
|---|---|---|---|---|---|---|
Breast cancer cases controls | ||||||
DCLRE1C | Chr10: 14,983,925–15,065,676 | 82 kb | 0/842 (-) | 0/497 (-) | NA | NA |
CASP3 | Chr4: 185,506,876–185,841,468 | 335 kb | 0/842 (-) | 0/497 (-) | NA | NA |
DAB2IP | Chr9: 124,201,774–124,361,084 | 159 kb | 0/842 (-) | 0/497 (-) | NA | NA |
ITGA9 | Chr3: 37,750,166–37,810,925 | 61 kb | 1/842 (0.1%) | 1/497 (0.2%) | 1.000 | 0.590 (0.037 – 9.450) |
CDH19 | Chr18: 64,082,045–64,335,669 | 254 kb | 12/842 (1.4%) | 3/497 (0.6%) | 0.168 | 2.381 (0.669 – 8.478) |
CYP2C19 | Chr10: 96,497,324–96,559,110 | 62 kb | 31/842 (3.7%) | 17/497 (3.4%) | 0.804 | 1.079 (0.591 – 1.971) |