Protein kinase C-delta inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo

Table 1 Comparison of three generations of PKCδ inhibitors

Generation	PKCδIC₅₀	PKCαIC₅₀	PKCδ/PKCα
			Selectivity ratio
1	3 μM	75 μM	28-fold
2	2 μM	157 μM	56-fold
3	0.05 μM	50 μM	1000-fold

ISSN: 1471-2407