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Table 1 Comparison of three generations of PKCδ inhibitors

From: Protein kinase C-delta inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo

Generation PKCδIC50 PKCαIC50 PKCδ/PKCα
    Selectivity ratio
1 3 μM 75 μM 28-fold
2 2 μM 157 μM 56-fold
3 0.05 μM 50 μM 1000-fold