Figure 7From: The effect of ROCK-1 activity change on the adhesive and invasive ability of Y79 retinoblastoma cells Rho/ROCK-1/LIMK2/cofilin signalling passway. ROCK-1 is downstream effector of Rho. ROCK-1 phosphorylates and activates LIM-kinase, which in turn phosphorylates and inactivates cofilin, and that regulates cell adhesion and invasion.Back to article page