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Table 4 Correlations between endogenous biomarkers and PET parameters analyzed from patients with HNSCC

From: Hypoxia, blood flow and metabolism in squamous-cell carcinoma of the head and neck: correlations between multiple immunohistochemical parameters and PET

  [18F]FDG [18F]FETNIM [15O]H20
  SUVa Tumor volumeb(cm3) FHVc(%) T/P ratiod Blood flow (ml/100 mg/min)
  rs p rs p rs p rs p rs p
GLUT-1 - 0.166 0.577 - 0.064 0.831 0.333 0.251 - 0.084 0.779 - 0.042 0.895
HIF-1α - 0.194 0.496 - 0.281 0.318 - 0.151 0.598 - 0.345 0.212 - 0.237 0.383
Ki-67 0.084 0.781 0.172 0.565 0 1 - 0.046 0.878 - 0.327 0.282
p53 0.470 0.078 0.428 0.113 - 0.269 0.340 0.074 0.799 0.020 0.948
CD-31 - 0.114 0.691 0.139 0.627 0.314 0.260 0.164 0.566 - 0.360 0.158
CD-68 - 0.046 0.872 - 0.007 0.980 0.039 0.892 - 0.093 0.747 - 0.086 0.776
Tunel - 0.414 0.127 - 0.386 0.159 - 0.064 0.824 - 0.125 0.663 0.072 0.810
  1. astandardized uptake value.
  2. bmetabolically active volume as determined from [18F]FDG PET.
  3. cfractional hypoxic volume.
  4. dmaximum tumor-to-plasma radioactivity at 90 – 120 min.
  5. rs = Spearman correlation coefficients.
  6. p = p-value.