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Table 4 Correlations between endogenous biomarkers and PET parameters analyzed from patients with HNSCC

From: Hypoxia, blood flow and metabolism in squamous-cell carcinoma of the head and neck: correlations between multiple immunohistochemical parameters and PET

 

[18F]FDG

[18F]FETNIM

[15O]H20

 

SUVa

Tumor volumeb(cm3)

FHVc(%)

T/P ratiod

Blood flow (ml/100 mg/min)

 

rs

p

rs

p

rs

p

rs

p

rs

p

GLUT-1

- 0.166

0.577

- 0.064

0.831

0.333

0.251

- 0.084

0.779

- 0.042

0.895

HIF-1α

- 0.194

0.496

- 0.281

0.318

- 0.151

0.598

- 0.345

0.212

- 0.237

0.383

Ki-67

0.084

0.781

0.172

0.565

0

1

- 0.046

0.878

- 0.327

0.282

p53

0.470

0.078

0.428

0.113

- 0.269

0.340

0.074

0.799

0.020

0.948

CD-31

- 0.114

0.691

0.139

0.627

0.314

0.260

0.164

0.566

- 0.360

0.158

CD-68

- 0.046

0.872

- 0.007

0.980

0.039

0.892

- 0.093

0.747

- 0.086

0.776

Tunel

- 0.414

0.127

- 0.386

0.159

- 0.064

0.824

- 0.125

0.663

0.072

0.810

  1. astandardized uptake value.
  2. bmetabolically active volume as determined from [18F]FDG PET.
  3. cfractional hypoxic volume.
  4. dmaximum tumor-to-plasma radioactivity at 90 – 120 min.
  5. rs = Spearman correlation coefficients.
  6. p = p-value.
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BMC Cancer

ISSN: 1471-2407

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