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Table 2 The association between the biomarkers of thyroid function/autoimmunity and thyroid cancer risk

From: Biomarkers of thyroid function and autoimmunity for predicting high-risk groups of thyroid cancer: a nested case–control study

  Controls (n = 257) Cases (n = 257) Crude OR (95% CI) Adjusted OR (95% CI)c
TT3 (ng/mL)     
  <1.2 88(34.2) 79(30.7) 1.0(ref) 1.0(ref)
  1.2 - <1.4 104(40.5) 109(42.4) 1.17(0.78 - 1.75) 1.18(0.78 - 1.79)
  ≥1.4 65(25.3) 69(26.9) 1.18(0.75 - 1.86) 1.21(0.75 - 1.94)
FT4 (ng/dL)     
  <1.25 85(33.1) 68(26.5) 1.0(ref) 1.0(ref)
  1.25 - <1.39 85(33.1) 75(29.2) 1.10(0.71 - 1.72) 1.05(0.66 - 1.65)
  ≥1.39 87(33.9) 114(44.4) 1.64(1.07 - 2.57)* 1.73(1.11 - 2.69)*
TSH (μIU/mL)     
  <1.36 84(33.1) 59(23.2) 1.0(ref) 1.0(ref)
  1.36 - <2.5 86(33.9) 111(43.7) 1.81(1.18 - 2.79)* 1.77(1.14 - 2.74)*
  ≥2.5 84(33.1) 84(33.1) 1.40(0.90 - 2.19) 1.37(0.87 - 2.16)
Tg (ng/mL)a     
  0 - <3.9 77(33.8) 67(29.7) 1.0(ref) 1.0(ref)
  3.9 - <7 74(32.5) 64(28.3) 0.98(0.61 - 1.56) 0.97(0.60 - 1.55)
  ≥7 77(33.8) 95(42.0) 1.40(0.90 - 2.17) 1.40(0.89 - 2.19)
TgAb (IU/mL)b     
  <20 212(82.5) 203(79.0) 1.0(ref) 1.0(ref)
  20 - <60 17(6.6) 25(9.7) 1.54(0.81 - 2.93) 1.58(0.82 - 3.06)
  ≥60 28(10.9) 29(11.3) 1.08(0.62 - 1.88) 1.13(0.64 - 2.00)
TPOAb (IU/mL)b     
  <30 192(74.1) 77(30.0) 1.0(ref) 1.0(ref)
  30 - <60 38(14.8) 131(51.0) 8.60(5.49 - 13.45)* 8.47(5.39 - 13.33)*
  ≥60 27(10.5) 49(19.1) 4.53(2.64 - 7.76)* 4.48(2.59 - 7.76)*
  1. Abbreviations: CI, Confidence interval; OR, Odds ratio; TT3, Total triiodothyronine; FT4, Free thyroxine; TSH, Thyroid-stimulating hormone; Tg, Thyroglobulin; TgAb, Anti-thyroglobulin antibody; TPOAb, Anti-thyroperoxidase antibody.
  2. aAnalyzed only for TgAb-negative subjects; bThe detection limits used were 20 IU/mL for TgAb and 30 IU/mL for TPOAb; cAdjusted for age, sex, BMI, and smoking.
  3. * P <0.05.