Table 2 The association between the biomarkers of thyroid function/autoimmunity and thyroid cancer risk
Controls (n = 257) | Cases (n = 257) | Crude OR (95% CI) | Adjusted OR (95% CI)c | |
|---|---|---|---|---|
TT3 (ng/mL) | ||||
<1.2 | 88(34.2) | 79(30.7) | 1.0(ref) | 1.0(ref) |
1.2 - <1.4 | 104(40.5) | 109(42.4) | 1.17(0.78 - 1.75) | 1.18(0.78 - 1.79) |
≥1.4 | 65(25.3) | 69(26.9) | 1.18(0.75 - 1.86) | 1.21(0.75 - 1.94) |
FT4 (ng/dL) | ||||
<1.25 | 85(33.1) | 68(26.5) | 1.0(ref) | 1.0(ref) |
1.25 - <1.39 | 85(33.1) | 75(29.2) | 1.10(0.71 - 1.72) | 1.05(0.66 - 1.65) |
≥1.39 | 87(33.9) | 114(44.4) | 1.64(1.07 - 2.57)* | 1.73(1.11 - 2.69)* |
TSH (μIU/mL) | ||||
<1.36 | 84(33.1) | 59(23.2) | 1.0(ref) | 1.0(ref) |
1.36 - <2.5 | 86(33.9) | 111(43.7) | 1.81(1.18 - 2.79)* | 1.77(1.14 - 2.74)* |
≥2.5 | 84(33.1) | 84(33.1) | 1.40(0.90 - 2.19) | 1.37(0.87 - 2.16) |
Tg (ng/mL)a | ||||
0 - <3.9 | 77(33.8) | 67(29.7) | 1.0(ref) | 1.0(ref) |
3.9 - <7 | 74(32.5) | 64(28.3) | 0.98(0.61 - 1.56) | 0.97(0.60 - 1.55) |
≥7 | 77(33.8) | 95(42.0) | 1.40(0.90 - 2.17) | 1.40(0.89 - 2.19) |
TgAb (IU/mL)b | ||||
<20 | 212(82.5) | 203(79.0) | 1.0(ref) | 1.0(ref) |
20 - <60 | 17(6.6) | 25(9.7) | 1.54(0.81 - 2.93) | 1.58(0.82 - 3.06) |
≥60 | 28(10.9) | 29(11.3) | 1.08(0.62 - 1.88) | 1.13(0.64 - 2.00) |
TPOAb (IU/mL)b | ||||
<30 | 192(74.1) | 77(30.0) | 1.0(ref) | 1.0(ref) |
30 - <60 | 38(14.8) | 131(51.0) | 8.60(5.49 - 13.45)* | 8.47(5.39 - 13.33)* |
≥60 | 27(10.5) | 49(19.1) | 4.53(2.64 - 7.76)* | 4.48(2.59 - 7.76)* |