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Figure 6 | BMC Cancer

Figure 6

From: MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NFκB-dependent pathway

Figure 6

MTDH contributed to trastuzumab resistance by decreasing PTEN expression in breast cancer model using athymic nude mice. A. Smaller tumor volumes in MTDH-shRNA group with trastuzumab injection in comparison with vector control group using SK-BR-3/R cells infected with scrambled shRNA (*P < 0.05); B. Tumor xenografts in MTDH-SK-BR-3 group outgrew other 3 groups. Compared with vector control group, tumor volumes were larger in MTDH-SK-BR-3 group than that in Vector-SK-BR-3 group treated with trastuzumab (*P < 0.05); C. Histological examination of tumor xenografts. Hematoxylin and eosin (HE) staining confirmed the existence of tumor and immunohistochemical analysis revealed distinct Ki67 and PTEN expressions in xenografts (magnification at 400×).

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BMC Cancer

ISSN: 1471-2407

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