Table 2 Univariate and multivariate Cox proportional hazards analysis for disease-free survival (Stage ll-lll) (N = 95)
From: Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancer
Variables | Categories | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Â | Â | HR (95% CI) | P value | HR (95% CI) | P value |
Depth (T factor) | T2 vs. T3, T4 | 1.40 (0.82-2.38) | NS | Â | Â |
Lymph node status | Positive vs. negative | 2.55 (1.25-5.20) | 0.01 | 3.46 (1.50-7.97) | 0.004 |
Heregulin expression | Positive vs. negative | 2.03 (1.04-3.94) | 0.037 | 1.72 (0.83-3.55) | NS |
EGFR expresion | Positive vs. negative | 1.76 (0.88-3.51) | NS | Â | Â |
pEGFR expression | Positive vs. negative | 4.08 (2.08-8.01) | <0.001 | 2.06 (0.94-4.55) | NS |
ErbB2 expression | Positive vs. negative | 1.83 (0.93-3.62) | NS | Â | Â |
pErbB2 expression | Positive vs. negative | 2.90 (1.44-5.81) | 0.003 | 1.05 (0.47-2.34) | NS |
EbB3 expression | Positive vs. negative | 2.24 (1.14-4.44) | 0.02 | 1.31 (0.61-2.85) | NS |
pErbB3 expression | Positive vs. negative | 3.76 (1.95-7.28) | <0.001 | 2.60 (1.06-6.37) | 0.036 |
ErbB4 expression | Positive vs. negative | 2.27 (1.15-4.49) | 0.018 | 0.69 (0.21-2.35) | NS |
pErbB4 expression | Positive vs. negative | 3.41 (1.25-5.20) | <0.001 | 5.24 (1.50-7.97) | 0.01 |