Skip to main content

Table 2 Univariate and multivariate Cox proportional hazards analysis for disease-free survival (Stage ll-lll) (N = 95)

From: Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancer

Variables Categories Univariate analysis Multivariate analysis
   HR (95% CI) P value HR (95% CI) P value
Depth (T factor) T2 vs. T3, T4 1.40 (0.82-2.38) NS   
Lymph node status Positive vs. negative 2.55 (1.25-5.20) 0.01 3.46 (1.50-7.97) 0.004
Heregulin expression Positive vs. negative 2.03 (1.04-3.94) 0.037 1.72 (0.83-3.55) NS
EGFR expresion Positive vs. negative 1.76 (0.88-3.51) NS   
pEGFR expression Positive vs. negative 4.08 (2.08-8.01) <0.001 2.06 (0.94-4.55) NS
ErbB2 expression Positive vs. negative 1.83 (0.93-3.62) NS   
pErbB2 expression Positive vs. negative 2.90 (1.44-5.81) 0.003 1.05 (0.47-2.34) NS
EbB3 expression Positive vs. negative 2.24 (1.14-4.44) 0.02 1.31 (0.61-2.85) NS
pErbB3 expression Positive vs. negative 3.76 (1.95-7.28) <0.001 2.60 (1.06-6.37) 0.036
ErbB4 expression Positive vs. negative 2.27 (1.15-4.49) 0.018 0.69 (0.21-2.35) NS
pErbB4 expression Positive vs. negative 3.41 (1.25-5.20) <0.001 5.24 (1.50-7.97) 0.01