Figure 1
From: Oxidative stress in susceptibility to breast cancer: study in Spanish population
The polymorphisms rs406113, rs974334, rs1052133 and rs2284659, showing the highest statistical significance in the combinatorial set 1 + set 2, were chosen for the gene-gene interaction analysis. The MDR analysis was done with the genotypes collapsed according to the genetic models selected: rs1052133 (OGG1) recessive model; CC/CG vs.GG, rs406113 (GPX6) dominant model; CC/AC vs. AA, rs974334 (GPX6) recessive model; CC/CG vs. GG, rs2284659 (SOD3) recessive model; GG/GT vs. TT. The figure shows the summary of four-loci genotype combinations associated with high and low risk. Cases: left bars, controls: right bars. The epistatic gene-gene interaction corresponds to the high risk combinations (darkest color).