Table 5 The relationship between the CTCAE grading of neuropathy and the scores of the individual EORTC QLQ-C30 scales and the effect size of the differences
From: Impact of late toxicities on quality of life for survivors of nasopharyngeal carcinoma
CTCAE grading of neuropathy | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Grade 0 (n = 196) | Grade 1 (n = 14) | Grade 2 (n = 18) | Grade 3 (n = 14) | ||||||||
Mean (SD) | Mean (SD) | Cohen’s D | ES | Mean (SD) | Cohen’s D | ES | Mean (SD) | Cohen’s D | ES | p | |
Global quality of life | 60 (18) | 54 (23) | 0.31 | M | 41 (22) | 0.95 | L | 33 (23) | 1.26 | L | <0.001 |
Physical functioning | 89 (13) | 88 (13) | 0.13 | S | 76 (22) | 0.75 | M | 61 (27) | 1.33 | L | <0.001 |
Role functioning | 91 (16) | 92 (14) | 0.00 | S | 80 (28) | 0.53 | M | 60 (28) | 1.38 | L | <0.001 |
Emotional functioning | 81 (17) | 82 (15) | 0.04 | S | 65 (24) | 0.77 | M | 61 (19) | 1.10 | L | <0.001 |
Cognitive functioning | 79 (18) | 77 (14) | 0.10 | S | 69 (22) | 0.48 | M | 58 (25) | 0.95 | L | 0.006 |
Social functioning | 82 (21) | 75 (13) | 0.37 | M | 62 (29) | 0.81 | L | 52 (26) | 1.28 | L | <0.001 |
Fatigue | 25 (20) | 25 (16) | 0.01 | S | 42 (27) | 0.70 | M | 46 (21) | 1.02 | L | 0.001 |
Nausea/Vomiting | 5 (11) | 4 (7) | 0.12 | S | 10 (14) | 0.42 | M | 15 (20) | 0.65 | M | 0.008 |
Pain | 16 (20) | 17 (20) | 0.04 | S | 37 (24) | 0.96 | L | 37 (26) | 0.90 | L | <0.001 |
Dyspnoea | 11 (17) | 8 (15) | 0.22 | S | 22 (26) | 0.47 | M | 21 (25) | 0.47 | M | NS |
Insomnia | 22 (24) | 23 (21) | 0.04 | S | 41 (24) | 0.76 | M | 40 (37) | 0.58 | M | 0.006 |
Appetite loss | 12 (20) | 7 (14) | 0.27 | S | 22 (26) | 0.46 | M | 24 (33) | 0.44 | M | NS |
Constipation | 17 (23) | 13 (22) | 0.17 | S | 28 (26) | 0.45 | M | 21 (28) | 0.18 | S | NS |
Diarrhoea | 10 (17) | 6 (13) | 0.31 | M | 19 (21) | 0.44 | M | 14 (22) | 0.21 | S | NS |
Financial problems | 20 (26) | 24 (24) | 0.16 | S | 46 (26) | 0.84 | L | 40 (32) | 0.71 | M | 0.001 |