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Table 5 The relationship between the CTCAE grading of neuropathy and the scores of the individual EORTC QLQ-C30 scales and the effect size of the differences

From: Impact of late toxicities on quality of life for survivors of nasopharyngeal carcinoma

  CTCAE grading of neuropathy  
  Grade 0 (n = 196) Grade 1 (n = 14) Grade 2 (n = 18) Grade 3 (n = 14)  
  Mean (SD) Mean (SD) Cohen’s D ES Mean (SD) Cohen’s D ES Mean (SD) Cohen’s D ES p
Global quality of life 60 (18) 54 (23) 0.31 M 41 (22) 0.95 L 33 (23) 1.26 L <0.001
Physical functioning 89 (13) 88 (13) 0.13 S 76 (22) 0.75 M 61 (27) 1.33 L <0.001
Role functioning 91 (16) 92 (14) 0.00 S 80 (28) 0.53 M 60 (28) 1.38 L <0.001
Emotional functioning 81 (17) 82 (15) 0.04 S 65 (24) 0.77 M 61 (19) 1.10 L <0.001
Cognitive functioning 79 (18) 77 (14) 0.10 S 69 (22) 0.48 M 58 (25) 0.95 L 0.006
Social functioning 82 (21) 75 (13) 0.37 M 62 (29) 0.81 L 52 (26) 1.28 L <0.001
Fatigue 25 (20) 25 (16) 0.01 S 42 (27) 0.70 M 46 (21) 1.02 L 0.001
Nausea/Vomiting 5 (11) 4 (7) 0.12 S 10 (14) 0.42 M 15 (20) 0.65 M 0.008
Pain 16 (20) 17 (20) 0.04 S 37 (24) 0.96 L 37 (26) 0.90 L <0.001
Dyspnoea 11 (17) 8 (15) 0.22 S 22 (26) 0.47 M 21 (25) 0.47 M NS
Insomnia 22 (24) 23 (21) 0.04 S 41 (24) 0.76 M 40 (37) 0.58 M 0.006
Appetite loss 12 (20) 7 (14) 0.27 S 22 (26) 0.46 M 24 (33) 0.44 M NS
Constipation 17 (23) 13 (22) 0.17 S 28 (26) 0.45 M 21 (28) 0.18 S NS
Diarrhoea 10 (17) 6 (13) 0.31 M 19 (21) 0.44 M 14 (22) 0.21 S NS
Financial problems 20 (26) 24 (24) 0.16 S 46 (26) 0.84 L 40 (32) 0.71 M 0.001
  1. Abbreviations: CTCAE: Common Terminology Criteria for Adverse Events, v4.0; EORTC QLQ-C30: European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30; SD: standard deviation; Cohen’s D was calculated relative to grade 0; ES: effect size based on Cohen’s D; S: small; M: moderate; L: large; NS: not significant.