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Table 1 Clinical characteristics of patient by anemia status

From: Impact of preoperative anemia on relapse and survival in breast cancer patients

  N = 2123 (%) Hb < 12 g/dL Hb ≥ 12 g/dL χ 2 P
   n = 535 (25.2%) n = 1588 (74.8%)   
Age      
  ≤50 1384 (65.2) 359 (67.1) 1025 (64.5) 1.152 0.283
  >50 739 (34.8) 176 (32.9) 563 (35.5)   
Tumor type      
  Invasive ductal carcinoma 1944 (91.6) 503 (94.0) 1441 (90.7) 5.561 0.018
  Other 179 (8.4) 32 (6.0) 147 (9.3)   
Tumor stage      
  T1 703 (33.1) 146 (27.3) 557 (35.1) 32.458 <0.001
  T2 1146 (54.0) 284 (53.1) 862 (54.3)   
  T3 and T4 274 (12.9) 105 (19.6) 169 (10.6)   
N stage      
  N0 1185 (55.8) 250 (46.7) 935 (58.8) 38.534 <0.001
  N1 603 (28.4) 159 (29.7) 444 (28.0)   
  N2 211 (9.9) 78 (14.6) 133 (8.4)   
  N3 124 (5.8) 48 (9.0) 76 (4.8)   
Histologic grading      
  G1G2 or Gx 1680 (79.1) 425 (79.4) 1255 (79.0) 0.041 0.840
  G3 443 (20.9) 110 (20.6) 333 (21.0)   
ER      
  Negative 846 (39.8) 226 (42.3) 620 (39.1) 6.385 0.041
  Positive 683 (32.2) 182 (34.0) 501 (31.5)   
  Strongly positive 594 (28.0) 127 (23.7) 467 (29.4)   
PR      
  Negative 654 (30.8) 168 (31.4) 486 (30.6) 8.078 0.018
  Positive 906 (42.7) 249 (46.5) 657 (41.4)   
  Strongly positive 563 (26.5) 118 (22.1) 445 (28.0)   
HER-2      
  Negative 1067 (50.3) 249 (46.5) 818 (51.5) 10.315 0.006
  Positive 633 (29.8) 154 (28.8) 479 (30.2)   
  Strongly positive 423 (19.9) 132 (24.7) 291 (18.3)   
BMI      
  Low (<18.5) 151 (7.1) 47 (8.8) 104 (6.6) 25.980 <0.001
  Normal (18.5–22.9) 929 (43.8) 276 (51.6) 653 (41.1)   
  High (>22.9) 1043 (49.1) 212 (39.6) 831 (52.3)   
Menopause      
  No 1318 (62.1) 352 (65.8) 966 (60.8) 4.188 0.041
  Yes 805 (37.9) 183 (34.2) 622 (39.2)   
Type of surgery      
  Modified radical mastectomy 2092 (98.5) 531 (99.3) 1561 (98.3) 2.524 0.112
  Breast-conserving surgery 31 (1.5) 4 (0.7) 27 (1.7)   
Chemotherapy      
  No 381 (17.9) 89 (16.6) 292 (18.4) 0.835 0.361
  Yes 1742 (82.1) 446 (83.4) 1296 (81.6)   
Radiotherapy      
  No 1842 (86.8) 452 (84.5) 1390 (87.5) 3.232 0.072
  Yes 281 (13.2) 83 (15.5) 198 (12.5)   
Hormonal therapy      
  No 1366 (64.3) 347 (64.9) 1019 (64.2) 0.083 0.773
  Yes 757 (35.7) 188 (35.1) 569 (35.8)   
Targeted therapy      
  No 2109 (99.3) 530 (99.1) 1579 (99.4) - 0.361a
  Yes 14 (0.7) 5 (0.9) 9 (0.6)   
  1. aFisher's exact test.
  2. Abbreviations: Hb hemoglobin, PR partial response, BMI body mass index.
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