Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer

Table 2 Relationship of EET-related gene expression and clinical characteristics of BC patients

Variable		CYP2C8			CYP2C9			CYP2J2			sEH
Variable		-	+	P value*	-	+	P value*	-	+	P value*	-	+	P value*
Age, years	≤50	12	4	0.573	8	8	0.292	12	4	0.573	12	10	0.618
	>50	16	8		8	16		16	8		12	6
Histological grade	I	8	2	0.821	8	6	0.879	14	2	0.036	6	4	0.131
Histological grade	II	12	6		6	8		10	4		8	10
	III	8	4		2	10		4	6		10	2
Tumor size, cm	≤2	8	0	0.058	6	3	0.089	9	1	0.047	2	7	0.021
	2-5	18	10		10	17		17	7		20	7
	≥5	2	2		0	4		2	4		2	2
Lymph node metastasis	Negative	14	4	0.332	12	12	0.114	19	5	0.166	10	6	0.792
Lymph node metastasis	Positive	14	8		4	12		9	7		14	10
ER status	-	6	8	0.011	4	10	0.279	8	6	0.193	4	10	0.003
	+	22	4		12	14		20	6		20	6
Ki67 proportion	≤14%	8	8	0.037	2	14	0.007	10	6	0.49	4	12	<0.001
Ki67 proportion	>14%	20	4		14	10		18	6		20	4
C-erb-B2 staining	−/+	22	6	0.13	14	14	0.079	24	8	0.221	20	10	0.159
C-erb-B2 staining	++/+++	6	6		2	10		4	4		4	6
PR status	-	6	2	1	2	6	0.439	8	0	0.079	8	5	0.89
	+	22	10		14	18		20	12		16	11

ER, estrogen receptors; PR, progesterone receptor.
*Spearman correlation was used to analyze the correlation of clinicopathological variables and EET-related genes expression.

ISSN: 1471-2407