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Table 2 Relationship of EET-related gene expression and clinical characteristics of BC patients

From: Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer

Variable CYP2C8 CYP2C9 CYP2J2 sEH
- + P value* - + P value* - + P value* - + P value*
Age, years ≤50 12 4 0.573 8 8 0.292 12 4 0.573 12 10 0.618
  >50 16 8   8 16   16 8   12 6  
Histological grade I 8 2 0.821 8 6 0.879 14 2 0.036 6 4 0.131
II 12 6   6 8   10 4   8 10  
  III 8 4   2 10   4 6   10 2  
Tumor size, cm ≤2 8 0 0.058 6 3 0.089 9 1 0.047 2 7 0.021
  2-5 18 10   10 17   17 7   20 7  
  ≥5 2 2   0 4   2 4   2 2  
Lymph node metastasis Negative 14 4 0.332 12 12 0.114 19 5 0.166 10 6 0.792
Positive 14 8   4 12   9 7   14 10  
ER status - 6 8 0.011 4 10 0.279 8 6 0.193 4 10 0.003
  + 22 4   12 14   20 6   20 6  
Ki67 proportion ≤14% 8 8 0.037 2 14 0.007 10 6 0.49 4 12 <0.001
>14% 20 4   14 10   18 6   20 4  
C-erb-B2 staining −/+ 22 6 0.13 14 14 0.079 24 8 0.221 20 10 0.159
++/+++ 6 6   2 10   4 4   4 6  
PR status - 6 2 1 2 6 0.439 8 0 0.079 8 5 0.89
  + 22 10   14 18   20 12   16 11  
  1. ER, estrogen receptors; PR, progesterone receptor.
  2. *Spearman correlation was used to analyze the correlation of clinicopathological variables and EET-related genes expression.
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