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Table 2 Multivariate Cox regression models based on EFS and OS, considering single prognostic markers and FOXP1 expression

From: FOXP1inhibits cell growth and attenuates tumorigenicity of neuroblastoma

Marker

Patients (N)

Available cases (N)

Hazard ratio

95% CI

P-value

Model considering single prognostic markers and FOXP1 expression based on EFS

476

471

   

  Age (<18 months vs. >18 months)

  

1.43

0.96-2.13

0.077

  Stage (stage 1-3, 4S vs. 4)

  

2.31

1.62-3.31

< 0.001

  MYCN status (normal vs. amplified)

  

1.74

1.20-2.52

0.005

  FOXP1 expression (cutoff EFS ≥27 840 vs. <27 840)

  

2.29

1.46-3.58

< 0.001

Model considering single prognostic markers and FOXP1 expression based on OS

476

471

   

  Age (<18 months vs. >18 months)

  

2.95

1.60-5.42

< 0.001

  Stage (stage 1-3, 4S vs. 4)

  

3.18

1.95-5.21

< 0.001

  MYCN status (normal vs. amplified)

  

2.89

1.86-4.51

< 0.001

  FOXP1 expression (cutoff OS ≥26 428 vs. <26 428)

  

1.79

0.98-3.26

< 0.001

  1. Abbreviations: CI confidence interval, EFS event-free survival, OS overall surviaval, vs. versus.
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BMC Cancer

ISSN: 1471-2407

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