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Table 2 Multivariate Cox regression models based on EFS and OS, considering single prognostic markers and FOXP1 expression

From: FOXP1inhibits cell growth and attenuates tumorigenicity of neuroblastoma

Marker Patients (N) Available cases (N) Hazard ratio 95% CI P-value
Model considering single prognostic markers and FOXP1 expression based on EFS 476 471    
  Age (<18 months vs. >18 months)    1.43 0.96-2.13 0.077
  Stage (stage 1-3, 4S vs. 4)    2.31 1.62-3.31 < 0.001
  MYCN status (normal vs. amplified)    1.74 1.20-2.52 0.005
  FOXP1 expression (cutoff EFS ≥27 840 vs. <27 840)    2.29 1.46-3.58 < 0.001
Model considering single prognostic markers and FOXP1 expression based on OS 476 471    
  Age (<18 months vs. >18 months)    2.95 1.60-5.42 < 0.001
  Stage (stage 1-3, 4S vs. 4)    3.18 1.95-5.21 < 0.001
  MYCN status (normal vs. amplified)    2.89 1.86-4.51 < 0.001
  FOXP1 expression (cutoff OS ≥26 428 vs. <26 428)    1.79 0.98-3.26 < 0.001
  1. Abbreviations: CI confidence interval, EFS event-free survival, OS overall surviaval, vs. versus.
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