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Figure 4 | BMC Cancer

Figure 4

From: Non-small cell lung cancer with EML4-ALKtranslocation in Chinese male never-smokers is characterized with early-onset

Figure 4

Representative images showing the association between ALK protein expression and carcinoma differentiation. H&E staining and immunohistochemistry using an antibody against ALK were performed on the same FFPE tissue section from an EML4-ALK-negative (A) or an EML4-ALK-positive (B) specimen. (A) Representative image showing the absence of any ALK protein in a well differentiated, EML4-ALK-negative carcinoma. (B) Representative image showing the aberrant expression of ALK protein in a poorly differentiated, EML4-ALK-positive carcinoma. (C) Representative image showing histopathology of mucinous cribriform carcinoma. (D) Representative image showing ALK immunostaining in a section adjacent to the one shown in panel (C).

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BMC Cancer

ISSN: 1471-2407

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