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Table 9 Multivariate Cox proportional hazards regression for OS after CNS metastases

From: Platinum sensitivity and CD133 expression as risk and prognostic predictors of central nervous system metastases in patients with epithelial ovarian cancer

Variable

HR (95% CI)

P value

Platinum resistance

5.13 (1.28-20.57)

0.021

CD133 expression in primary ovarian cancer

2.82 (0.66-12.17)

0.163

Multiple CNS metastases

1.11 (0.20-6.12)

0.921

Multimodal therapy including SRS (SRS +/− neurosurgery +/− chemotherapy) for CNS metastases

0.12 (0.03-0.55)

0.007

CD133 cluster formation in CNS metastases

12.08 (1.55-94.16)

0.017

  1. Abbreviations: TAH Total abdominal hysterectomy, BSO Bilateral salpingo-oophorectomy, KPS Karnofsky performance status, WBRT Whole-brain radiation therapy, SRS Stereotactic radiosurgery.
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BMC Cancer

ISSN: 1471-2407

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