ROCK1 as a novel prognostic marker in vulvar cancer

BMC Cancer

Table 1 Multivariate analysis of ROCK1 expression and clinicopathological characteristics in patients with vulvar SCC

Variables	Category	n	Hazard ratio for survival	95.0% CI	p
Histologic types	SCC1, SCC2, Verrucous Ca (1)	76	1	1	0.6177
Histologic types	SCC3, Basaloid Ca, Sarcomatoid Ca(2)	20	0.78	0.30 - 2.05	0.6177
FIGO stage	IA, IB, II (1)	54	1	1	0.2083
FIGO stage	IIA, IIIB, IIIC, IVA, IVB (2)	40	1.62	0.76 - 3.47	0.2083
HPV	Absent (0)	50	1	1	0.2238
HPV	Present (1)	46	0.63	0.30 - 1.33	0.2238
Inflammatory infiltrate	Absent (0)	38	1	1	0.4964
Inflammatory infiltrate	Present (1)	58	0.77	0.36 - 1.64	0.4964
Vascular Invasion	Absent (0)	74	1	1	0.0365*
Vascular Invasion	Present (1)	17	2.22	1.03 - 4.77	0.0365*
Perineural invasion	Absent (0)	76	1	1	0.4178
Perineural invasion	Present (1)	12	1.43	0.60 - 3.38	0.4178
ROCK1 CT	Weak expression	22	1	1	0.6653
	Moderate expression	55	0.70	0.28 - 1.75
	Strong expression	19	0.95	0.34 - 2.67
ROCK1 IF	Weak expression	8	1	1	0.0054*
ROCK1 IF	Moderate expression	53	0.22	0.08 - 0.60	0.0054*
	Strong expression	35	0.30	0.11 -0.84

Abbreviations: SCC squamous cell carcinomas, CI confidence interval, FIGO International Federation of Gynecology and Obstetrics, HPV human papillomavirus, SMD superficial and mid dermis, DDA deep dermis and subcutaneous tissues, CT central tumour and IF invasive front. *Statistically significant, p < 0.05.

ISSN: 1471-2407