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Table 1 Multivariate analysis of ROCK1 expression and clinicopathological characteristics in patients with vulvar SCC

From: ROCK1 as a novel prognostic marker in vulvar cancer

Variables Category n Hazard ratio for survival 95.0% CI p
Histologic types SCC1, SCC2, Verrucous Ca (1) 76 1 1 0.6177
SCC3, Basaloid Ca, Sarcomatoid Ca(2) 20 0.78 0.30 - 2.05
FIGO stage IA, IB, II (1) 54 1 1 0.2083
IIA, IIIB, IIIC, IVA, IVB (2) 40 1.62 0.76 - 3.47
HPV Absent (0) 50 1 1 0.2238
Present (1) 46 0.63 0.30 - 1.33
Inflammatory infiltrate Absent (0) 38 1 1 0.4964
Present (1) 58 0.77 0.36 - 1.64
Vascular Invasion Absent (0) 74 1 1 0.0365*
Present (1) 17 2.22 1.03 - 4.77
Perineural invasion Absent (0) 76 1 1 0.4178
Present (1) 12 1.43 0.60 - 3.38
ROCK1 CT Weak expression 22 1 1 0.6653
Moderate expression 55 0.70 0.28 - 1.75
Strong expression 19 0.95 0.34 - 2.67
ROCK1 IF Weak expression 8 1 1 0.0054*
Moderate expression 53 0.22 0.08 - 0.60
  Strong expression 35 0.30 0.11 -0.84  
  1. Abbreviations: SCC squamous cell carcinomas, CI confidence interval, FIGO International Federation of Gynecology and Obstetrics, HPV human papillomavirus, SMD superficial and mid dermis, DDA deep dermis and subcutaneous tissues, CT central tumour and IF invasive front. *Statistically significant, p < 0.05.