From: MicroRNA-21 and the clinical outcomes of various carcinomas: a systematic review and meta-analysis
Study & year | Cancer | Cancer type(system) | Sample size | Country | Stage | Age | Follow-up (months) | Comparisons | Cut off value | Method |
---|---|---|---|---|---|---|---|---|---|---|
Nagao 2012 [17] | PDAC | Other | 79 | Japan | I-IV | 65 | 40 | NG | Mean | qRT-PCR |
Shibuya 2010 [31] | CRC | Digestive | 156 | Japan | *A-D | 65 | 60 | Normal tissues& | Mean | qRT-PCR |
Gao 2010 [11] | NSCLC | Respiratory | 47 | China | I-III | 64 | 60 | Normal tissues | Median | qRT-PCR |
Childs 2009 [32] | HNSCC | Other | 104 | USA | I-IV | 60 | 60 | Normal tissues | Mean | qRT-PCR |
Yan 2008 [33] | BC | Breast | 113 | China | I-III | 48 | 66.2 | Normal tissues | Mean | qRT-PCR |
Lee 2011 [35] | BC | Breast | 109 | Korea | I-III | 48 | 100 | NG | Mean | qRT-PCR |
Jiang 2011 [36] | Melanoma | Other | 106 | China | I-IV | 60 | 60 | NG | Median | qRT-PCR |
Zhi 2010 [37] | Astrocytoma | Other | 124 | China | I-IV | 47.8 | 35.2 | NG | Median | qRT-PCR |
Jamieson 2012 [38] | PDAC | Other | 58 | UK | II,III | 65 | 23.9 | Normal tissues | Median | qRT-PCR |
Schetter 2008 [39] | CRC | Digestive | 84 | USA | I-IV | 64.6 | 68.0 | Normal tissues | Highest tertile | qRT-PCR |
Schetter 2008 [39] | CRC | Digestive | 113 | HK | I-IV | 55.8 | 84.6 | Normal tissues | Dichotomize | Microarray |
Faltejskova 2012 [41] | CRC | Digestive | 44 | Czech | I-IV | 67 | 84 | Normal tissues | Median | qRT-PCR |
Chen 2013 [42] | CRC | Digestive | 195 | Taiwan | I-IV | 66 | 60 | Normal tissues | Mean | qRT-PCR |
Toiyama 2013 [43] | CRC | Digestive | 186 | Japan | I-IV | 67 | 60 | Normal tissues | 0.0031 | qRT-PCR |
Markou 2008 [13] | NSCLC | Respiratory | 48 | USA | I-IV | 60 | 50 | Healthy controls | 2-fold | qRT-PCR |
Liu2012 [44] | NSCLC | Respiratory | 70 | China | I-IV | 60 | 30 | Healthy controls | 2-fold | qRT-PCR |
Saito2011 [45] | NSCLC | Respiratory | 89 | USA | I-III | 63.6 | 80 | Normal tissues | Median | qRT-PCR |
Saito2011 [45] | NSCLC | Respiratory | 37 | Norway | I-III | 64.4 | 80 | Normal tissues | Median | qRT-PCR |
Saito2011 [45] | NSCLC | Respiratory | 191 | Japan | I-III | 59.6 | 80 | Normal tissues | Median | qRT-PCR |
Markou 2013 [46] | NSCLC | Respiratory | 48 | Greece | I-IV | 60 | 40 | Normal tissues | 6.3-fold | qRT-PCR |
Wu2013 [56] | Glioma | Other | 152 | China | I-IV | 45.1 | 60 | Normal tissues | Mean | qRT-PCR |
Papaconstantinou2012 [57] | PC | Other | 88 | Greece | I-IV | 66.5 | 40 | Normal tissues | Mean | qRT-PCR |
Karakatsanis2011 [48] | HCC | Digestive | 60 | Greece | I-IV | 60 | 50 | Healthy controls | Mean | qRT-PCR |
Kadera2013 [49] | PDAC | Other | 153 | USA | I, II,IV | 65 | 42 | Healthy controls | Median | ISH |
Markou 2014 [58] | BC | Breast | 112 | Greece | Â | 60 | 75 | Normal tissues | Median | qRT-PCR |
Akagi2013 [50] | LC | Respiratory | 67 | USA | I | 64.9 | 60 | Normal tissues | Median | qRT-PCR |
Akagi2013 [50] | LC | Respiratory | 25 | Norway | I | 64.0 | 60 | Normal tissues | Median | qRT-PCR |
Bovell2013 [51] | CC | Digestive | 345 | USA | IV | 65 | 17 | Normal tissues | Mean | qRT-PCR |
Capodanno 2013 [52] | NSCLC | Respiratory | 80 | Italy | I-IV | 67 | 32 | Normal tissues | Median | qRT-PCR |
Faragalla2012 [53] | RCC | Digestive | 121 | Canada | I-III | 62.4 | 52.8 | Normal tissues | 40th percentile | qRT-PCR |
Mathe 2009 [55] | ESCC | Digestive | 69 | Two countries | I-IV | 62 | 62.5 | Normal tissues | Dichotomize | qRT-PCR |