Figure 4

Tumor necrosis 72 hours after infusion of different doses of MECA32-Fab-TF. The results of two different studies are shown here. The largest tumor cross sections were submitted for histology and studied. Necrotic tumors and viable residual tumors were outlined as areas of pink and blue, respectively. The relative size of necrotic and viable tumor tissue was measured based on two dimensional areas. Percentages shown in the figure represent relative necrotic area in tumor sections. In study I, all three control tumors at right showed no necrosis (0%). In study II, photomicrographs of residual viable tumor and adjacent necrotic tumor tissue are shown at a higher magnification of 12.5x on the right. A 40x magnification to show few layers of residual viable tumor cells is shown in the inset.