mRNA expression of AdipoR1 and AdipoR2 in controls and patients with advanced adenoma and CRC. (a, b) AdipoR1 and AdipoR2 mRNA expression levels in advanced adenoma and CRC tissues were significantly lower than those in the control group. AdipoRs mRNA expression levels were not significantly different between advanced adenoma and the CRC tissues. The top and bottom of the boxes are the 25th and 75th percentiles. The difference between the quartiles is the interquartile range. The line across the middle of the box shows the median value. * p <0.05, ** p <0.001.