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Table 1 List of the top and bottom most regulated genes for each cell line in the C vs H and C’ vs H’ comparisons

From: A genomics approach to identify susceptibilities of breast cancer cells to “fever-range” hyperthermia

Gene symbol Gene name Accession number MCF-10A MCF-7 MDA-231 MDA-468
MCF10A       
XAGE1A X antigen family, member 1A, TV3 NM_001097593.1 64.0 1.2 1.0 122.0
XAGE1B X antigen family, member 1B, TV1 NM_001097595.1 60.3 1.2 1.1 131.6
SRGN Serglycin, TV1 NM_002727.2 58.1 1.1 -1.5 65.8
SRGN Serglycin, TV1 NM_002727.2 56.5 1.2 -1.5 67.7
LOC652683 Similar to sperm protein associated with the nucleus, X chromosome, family member B1 XM_942283.2 50.0 1.2 -1.0 71.5
SPANXA2 SPANX family, member A2 NM_145662.2 49.3 1.2 -1.1 67.7
SPANXB1 SPANX family, member B1 NM_032461.2 48.7 1.2 -1.0 70.0
TOP2A Topoisomerase (DNA) II alpha 170 kDa NM_001067.2 39.0 -2.0 -3.7 1.1
LOC653219 Similar to G antigen, family D, 2 isoform 1a, TV1 XM_927237.1 37.0 1.2 1.1 71.8
LOC100133171 Hypothetical protein LOC100133171 XM_001713741.1 34.8 1.3 -1.1 52.7
RN5S9 RNA, 5S ribosomal 9 NR_023371.1 -48.2 11.5 59.7 11.5
RN7SK RNA, 7SK small nuclear NR_001445.1 -55.1 13.1 45.4 38.6
SERPINB5 Serpin peptidase inhibitor, clade B (ovalbumin), member 5 NM_002639.3 -65.8 1.2 7.6 -3.8
KIAA1666 KIAA1666 protein XM_942124.2 -72.9 17.9 33.4 35.3
AKR1C2 Aldo-keto reductase family 1, member C2, TV1 NM_001354.4 -82.3 1.4 24.4 -9.6
LOC650517 Hypothetical LOC650517 XR_019109.1 -90.0 1.2 1.7 -2.0
RN7SK RNA, 7SK small nuclear NR_001445.1 -109.9 20.2 62.1 45.2
KRT17P3 Predicted misc_RNA KRT17P3 XR_015626.2 -133.2 1.5 2.6 -4.5
LOC651397 Predicted misc_RNA LOC651397 XR_037048.1 -141.4 1.2 5.1 -4.1
KRT6A Keratin 6A NM_005554.3 -242.8 1.2 116.7 -11.7
MCF7       
RNY5 RNA, Ro-associated Y5 NR_001571.2 -17.4 22.6 4.6 4.3
RN7SK RNA, 7SK small nuclear NR_001445.1 -109.9 20.2 62.1 45.2
KIAA1666 KIAA1666 protein XM_942124.2 -72.9 17.9 33.4 35.3
MIR1974 MicroRNA 1974 NR_031738.1 -9.4 14.2 20.8 133.3
LOC100008589 28S ribosomal RNA NR_003287.1 -26.8 13.8 26.4 113.8
RN7SK RNA, 7SK small nuclear NR_001445.1 -55.1 13.1 45.4 38.6
LOC100132394 Hypothetical protein LOC100132394 XM_001713809.1 -19.4 12.3 22.2 105.0
RNU4-1 RNA, U4 small nuclear 1 NR_003925.1 -7.7 11.5 11.4 13.2
RN5S9 RNA, 5S ribosomal 9 NR_023371.1 -48.2 11.5 59.7 11.5
SNORD3C Small nucleolar RNA, C/D box 3C NR_006881.1 -34.9 11.1 30.5 11.8
CCDC117 Coiled-coil domain containing 117 NM_173510.1 3.2 -3.3 -1.7 -1.8
LOC730432 Hypothetical protein LOC730432 XM_001125680.1 3.7 -3.3 -1.3 -4.7
LOC644799 Hypothetical protein LOC644799, TV1 XM_934554.1 2.5 -3.3 -2.1 1.1
RPS6KB1 Ribosomal protein S6 kinase, 70 kDa, polypeptide 1 NM_003161.2 2.9 -3.4 -1.8 -3.7
NRIP1 Nuclear receptor interacting protein 1 NM_003489.2 1.1 -3.4 -1.8 -4.2
AP4E1 Adaptor-related protein complex 4, epsilon 1 subunit NM_007347.3 2.3 -3.4 -2.1 -2.2
DCP2 DCP2 decapping enzyme homolog (S. cerevisiae), TV1 NM_152624.4 3.1 -3.4 -2.4 -6.8
TROVE2 TROVE domain family, member 2, TV1 NM_001042369.1 2.0 -3.8 -1.2 -8.2
PURB Purine-rich element binding protein B NM_033224.3 3.2 -3.8 -2.6 -7.1
ZNF217 Zinc finger protein 217 NM_006526.2 3.2 -3.9 -1.7 -2.5
MDA231       
KRT6A Keratin 6A NM_005554.3 -242.8 1.2 116.7 -11.7
RN7SK RNA, 7SK small nuclear NR_001445.1 -109.9 20.2 62.1 45.2
RN5S9 RNA, 5S ribosomal 9 NR_023371.1 -48.2 11.5 59.7 11.5
RN7SK RNA, 7SK small nuclear NR_001445.1 -55.1 13.1 45.4 38.6
SNORD3D Small nucleolar RNA, C/D box 3D NR_006882.1 -47.2 11.1 36.8 9.4
SNORD3A Small nucleolar RNA, C/D box 3A NR_006880.1 -46.0 11.1 36.5 9.0
KIAA1666 KIAA1666 protein XM_942124.2 -72.9 17.9 33.4 35.3
SNORD3C Small nucleolar RNA, C/D box 3C NR_006881.1 -34.9 11.1 30.5 11.8
LOC100008589 28S ribosomal RNA NR_003287.1 -26.8 13.8 26.4 113.8
LOC100132564 Hypothetical protein LOC100132564 XM_001713808.1 -21.6 8.4 25.3 13.3
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 NM_002577.3 5.9 -2.9 -3.1 -1.3
CEP55 Centrosomal protein 55 kDa, TV1 NM_018131.3 19.2 -1.7 -3.2 -1.2
RHOBTB3 Rho-related BTB domain containing 3 NM_014899.3 14.0 -1.1 -3.2 2.5
ZAK Sterile alpha motif and leucine zipper containing kinase AZK, V2 NM_133646.2 2.8 -2.6 -3.2 -4.0
KATNAL1 Katanin p60 subunit A-like 1, TV2 NM_001014380.1 3.6 -1.4 -3.2 -1.3
PBK PDZ binding kinase NM_018492.2 10.5 -1.9 -3.3 -1.0
PAFAH1B1 Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit NM_000430.2 4.5 -2.6 -3.5 1.2
TOP2A Topoisomerase (DNA) II alpha 170 kDa NM_001067.2 39.0 -2.0 -3.7 1.1
FAM83D Family with sequence similarity 83, member D NM_030919.2 15.4 -1.8 -4.0 -1.7
BCAT1 Branched chain aminotransferase 1, cytosolic NM_005504.4 8.9 1.1 -4.9 2.9
MDA468       
MIR1974 microRNA 1974 NR_031738.1 -9.4 14.2 20.8 133.3
XAGE1B X antigen family, member 1B, TV1 NM_001097595.1 60.3 1.2 1.1 131.6
XAGE1A X antigen family, member 1A, TV3 NM_001097593.1 64.0 1.2 1.0 122.0
LOC100008589 28S ribosomal RNA NR_003287.1 -26.8 13.8 26.4 113.8
LOC100132394 Hypothetical protein LOC100132394 XM_001713809.1 -19.4 12.3 22.2 105.0
CST3 Cystatin C NM_000099.2 -1.8 1.2 1.7 103.9
ACTG1 Actin, gamma 1 NM_001614.2 1.1 1.5 1.5 75.2
LOC653219 Similar to G antigen, family D, 2 isoform 1a, XM_927237.1 37.0 1.2 1.1 71.8
LOC652683 Similar to sperm protein associated with the nucleus, X chromosome, family member B1 XM_942283.2 50.0 1.2 -1.0 71.5
SPANXB1 SPANX family, member B1 NM_032461.2 48.7 1.2 -1.0 70.0
CSAG1 Chondrosarcoma associated gene 1, TVb NM_153479.1 1.7 1.2 -1.0 -27.4
SERPINA3 Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 NM_001085.4 -8.5 1.1 2.0 -30.5
ALDH1A3 Aldehyde dehydrogenase 1 family, member A3 NM_000693.1 -1.5 -1.0 2.0 -34.0
EPCAM Epithelial cell adhesion molecule NM_002354.2 1.6 -1.2 -1.2 -36.1
LAD1 Ladinin 1 NM_005558.3 -47.9 1.2 13.5 -37.5
OLFML3 Olfactomedin-like 3 NM_020190.2 -1.2 1.2 1.2 -39.0
TACSTD1 Tumor-associated calcium signal transducer 1 NM_002354.1 2.1 -1.1 -1.4 -47.5
RARRES1 Retinoic acid receptor responder (tazarotene induced) 1, TV1 NM_206963.1 -1.3 1.3 -1.1 -49.9
MGP Matrix Gla protein NM_000900.2 -18.6 1.0 2.4 -51.1
KLK5 Kallikrein-related peptidase 5, TV1 NM_012427.4 -1.3 1.1 1.1 -56.3