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Table 5 Frequency of gene specific methylation according to case or control status and cytology group

From: Tumour suppressor gene methylation and cervical cell folate concentration are determinants of high-risk human papillomavirus persistence: a nested case control study

  Frequency of sample methylation [%]
DAPK CDH1 MGMT MLH1 P16
Case Control Case Control Case Control Case Control Case Control
Mild 26.5 [13/49] 14 [7/50] 32.7 [16/49] 40 [20/50] 12.2 [6/49] 10 [5/50] 0 [0/49] 0 [0/50] 2.0 [1/49] 0 [0/50]
Borderline 28 [14/50] 14 [7/50] 42 [21/50] 56 [28/50] 14 [7/50] 10 [5/50] 0 [0/50] 0 [0/50] 0 [0/50] 0 [0/50]
Normal 6 [6/100] 6 [6/100] 26 [26/100] 33 [33/100] 10 [10/100] 10 [10/100] 1 [1/100] 0 [0/100] 5 [5/100] 7 [7/100]
Total 23.6a [47/199] 17 [34/200] 31.7 [63/199] 40.5b [81/200] 11.6 [23/199] 5.5 [11/200] 0.05 [1/199] 0 [0/200] 3 [6/199] 3.5 [7/200]
  1. Promoter methylation of selected tumour suppressor genes, expressed as a percentage of women in each group. Values are shown for cases and controls, according to cytology group.
  2. aSignificantly greater than controls, P = 0.001; bSignificantly greater than cases, P = 0.016.
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