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Table 7 Analysis of OS according to KRAS mutation status in 205 BRAF wt colorectal cancer patients by cox regression analysis

From: BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients

     Univariate analysis Multivariate analysis
KRAS BRAF Total N No. of events HR (95% CI) P HR (95% CI) P
wt wt 109 22 1.0   1.0  
All codon 12 mutants wt 71 20 1.6 (0.9-2.9) 0.139 1.4 (0.8-2.6) 0.247
All codon 13 mutants wt 25 10 2.5 (1.2-5.2) 0.019 2.7 (1.3-5.7) 0.011
  1. NOTE: We tested KRAS codon 12 and 13 mutations among BRAF wild type cases.
  2. The multivariate Cox regression model initially included age, sex, tumor location, tumor differentiation, tumor diameter, number of lymph nodes examined, TNM stage, KRAS and PIK3CA status. A backward stepwise elimination with a threshold of P = 0.1 was used to select variables in the final model. TNM stage and KRAS status were finally entered the multivariate analysis. P-values ≤ 0.05 are in bold.