|  |  |  | Univariate analysis | Multivariate analysis |
---|
KRAS
|
BRAF
| Total N | No. of events | HR (95% CI) | P | HR (95% CI) | P |
---|
wt | wt | 109 | 22 | 1.0 | Â | 1.0 | Â |
All codon 12 mutants | wt | 71 | 20 | 1.6 (0.9-2.9) | 0.139 | 1.4 (0.8-2.6) | 0.247 |
All codon 13 mutants | wt | 25 | 10 | 2.5 (1.2-5.2) |
0.019
| 2.7 (1.3-5.7) |
0.011
|
- NOTE: We tested KRAS codon 12 and 13 mutations among BRAF wild type cases.
- The multivariate Cox regression model initially included age, sex, tumor location, tumor differentiation, tumor diameter, number of lymph nodes examined, TNM stage, KRAS and PIK3CA status. A backward stepwise elimination with a threshold of P = 0.1 was used to select variables in the final model. TNM stage and KRAS status were finally entered the multivariate analysis. P-values ≤ 0.05 are in bold.