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Table 6 Analysis of OS in 126 colon cancer patients by Cox regression analysis

From: BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients

Variables Univariate analysis Multivariate analysis
HR (95% CI) P HR (95% CI) P
Age   0.995   
<=65 1.0    
>65 1.0 (0.5-2.108)    
Sex   0.009   0.009
Female 1.0   1.0  
Male 3.0 (1.3-7.0)   3.3 (1.3-7.8)  
Differentiation   0.160   
well 1.0    
moderate 0.5 (0.2-1.1) 0.089   
poor 1.0 (0.3-3.9) 0.962   
Lymphnode examined   0.052   
>12 1.0    
<=12 2.0 (1.0-4.1)    
Tumor diameter   0.188   
<5 cm 1.0    
> = 5 cm 1.7 (0.8-3.5)    
TNM-stage   <0.001   0.017
I 1.0   1.0  
II 1.4 (0.2-10.8) 0.749 1.3 (0.2-9.9)  
III 1.8 (0.2-13.9) 0.568 2.1 (0.3-15.9)  
IV 9.7 (1.2-78.3) 0.032 5.8 (0.7-47.8)  
KRAS status   0.795   
wt 1.0    
mutant 1.1 (0.5-2.2)    
BRAF V600E status   <0.001   0.004
wt 1.0   1.0  
mutant 5.1 (2.1-12.4)   4.2 (1.6-11.0)  
PIK3CA status   0.727   
wt 1.0    
mutant 1.2 (0.5-2.8)    
  1. P-values ≤ 0.05 are in bold.