Variables | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Age | Â | 0.995 | Â | Â |
<=65 | 1.0 | Â | Â | Â |
>65 | 1.0 (0.5-2.108) | Â | Â | Â |
Sex | Â | 0.009 | Â | 0.009 |
Female | 1.0 | Â | 1.0 | Â |
Male | 3.0 (1.3-7.0) | Â | 3.3 (1.3-7.8) | Â |
Differentiation | Â | 0.160 | Â | Â |
well | 1.0 | Â | Â | Â |
moderate | 0.5 (0.2-1.1) | 0.089 | Â | Â |
poor | 1.0 (0.3-3.9) | 0.962 | Â | Â |
Lymphnode examined | Â | 0.052 | Â | Â |
>12 | 1.0 | Â | Â | Â |
<=12 | 2.0 (1.0-4.1) | Â | Â | Â |
Tumor diameter | Â | 0.188 | Â | Â |
<5Â cm | 1.0 | Â | Â | Â |
> = 5 cm | 1.7 (0.8-3.5) |  |  |  |
TNM-stage | Â | <0.001 | Â | 0.017 |
I | 1.0 | Â | 1.0 | Â |
II | 1.4 (0.2-10.8) | 0.749 | 1.3 (0.2-9.9) | Â |
III | 1.8 (0.2-13.9) | 0.568 | 2.1 (0.3-15.9) | Â |
IV | 9.7 (1.2-78.3) | 0.032 | 5.8 (0.7-47.8) | Â |
KRAS status | Â | 0.795 | Â | Â |
wt | 1.0 | Â | Â | Â |
mutant | 1.1 (0.5-2.2) | Â | Â | Â |
BRAF V600E status | Â | <0.001 | Â | 0.004 |
wt | 1.0 | Â | 1.0 | Â |
mutant | 5.1 (2.1-12.4) | Â | 4.2 (1.6-11.0) | Â |
PIK3CA status | Â | 0.727 | Â | Â |
wt | 1.0 | Â | Â | Â |
mutant | 1.2 (0.5-2.8) | Â | Â | Â |