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Table 6 Analysis of OS in 126 colon cancer patients by Cox regression analysis

From: BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients

Variables

Univariate analysis

Multivariate analysis

HR (95% CI)

P

HR (95% CI)

P

Age

 

0.995

  

<=65

1.0

   

>65

1.0 (0.5-2.108)

   

Sex

 

0.009

 

0.009

Female

1.0

 

1.0

 

Male

3.0 (1.3-7.0)

 

3.3 (1.3-7.8)

 

Differentiation

 

0.160

  

well

1.0

   

moderate

0.5 (0.2-1.1)

0.089

  

poor

1.0 (0.3-3.9)

0.962

  

Lymphnode examined

 

0.052

  

>12

1.0

   

<=12

2.0 (1.0-4.1)

   

Tumor diameter

 

0.188

  

<5 cm

1.0

   

> = 5 cm

1.7 (0.8-3.5)

   

TNM-stage

 

<0.001

 

0.017

I

1.0

 

1.0

 

II

1.4 (0.2-10.8)

0.749

1.3 (0.2-9.9)

 

III

1.8 (0.2-13.9)

0.568

2.1 (0.3-15.9)

 

IV

9.7 (1.2-78.3)

0.032

5.8 (0.7-47.8)

 

KRAS status

 

0.795

  

wt

1.0

   

mutant

1.1 (0.5-2.2)

   

BRAF V600E status

 

<0.001

 

0.004

wt

1.0

 

1.0

 

mutant

5.1 (2.1-12.4)

 

4.2 (1.6-11.0)

 

PIK3CA status

 

0.727

  

wt

1.0

   

mutant

1.2 (0.5-2.8)

   
  1. P-values ≤ 0.05 are in bold.