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Table 5 Interacting miRNAs and mRNAs in HGSC - differentially* and inversely expressed

From: Global miRNA expression analysis of serous and clear cell ovarian carcinomas identifies differentially expressed miRNAs including miR-200c-3p as a prognostic marker

miRNAs and mRNA targets FC values
miR-1341,5 -16.7
 KLHL141, PAX8 1,3,5 9.6 – 29.3
miR-141-3p 1,2,6/ miR-200a-3p 1,2,6 46.1
FOXP2 1,2,5, HLF1, PCDH95, PEG3 1,6, SCN7A1, SDC21,2,3,4,5,6 -9.6 – -24.7
miR-182-5p 1,2 30.2
 ANGPTL11,2,5, CACNB21,5, FOXP2 1,2,5, KCNMB21,5, PID11, SDC21,2,3,4,5,6, TMEM150C -9.6 – -14.6
miR-183-5p 1,2,6 11.7
ABCA8 1, HLF1 -11.6 – -17.8
miR-187-3p1 12.8
 TSPAN51,2 -11.3
miR-200b-3p 1,2,6/ miR-200c-3p 1,2,6 29.1
 CACNB21,5,CDH111,2,5,6, COL4A31,2,5,6, GPM6A1, HLF1, HS3ST3A11, LEPR1,2,4,5,6, MCC1,2, NEGR11,2,6, SDC21,2,3,4,5,6 -9.6 – -21.6
miR-202-3p -36.9
RRM2 1,2,4,6 16.9
miR-203-3p 1,2,6 13.6
 ANGPTL11,2,5, EDNRA1,2,6, FOXP2 1,2,5,GNG42,6, IGFBP51,2,3,4,5,6, NEGR11,2,6, SMAD91 -9.7 – -15.0
miR-205-5p 1,6 105.1
 BAMBI1,2,5,6, NR3C21,2,5,6, PEG3 1,6 -10.1 – -24.7
miR-376c-3p1 -11.7
 EHF1,2,3,6, LRP8 1,5,6 11.9 – 12.6
miR-379-5p -10.3
 KLHL141 29.3
miR-381-3p1 -12.6
 EGFL61, NOTCH3 1,2,3,5,6, RRM2 1,2,4,6 9.7 – 16.9
miR-383 -33.7
 MAL2 32.8
miR-424-5p 1,2,3,4,5,6 -26.0
 AHNAK21, CCNE1 1,2,3,4,6, ESRP1 1,6, HMGA1 1,2,3,4,6, LAMP31,2, PSAT1 1, UCP2 2,5, VAMP81,2 9.9 – 24.0
miR-485-5p1 -13.6
 KRT71,3,4, LRP8 1,5,6, ST141 10.5 – 16.2
miR-887 -9.6
 TMEM139 11.7
miR-4324 -12.5
ERBB3 1,2,3,5,6, GALNT6 17.9 – 23.7
  1. HGSC: High-grade serous ovarian carcinoma. *ANOVA, FDR < 5%, FC ≥ ±10 in HGSC vs. ovarian surface epithelium. All interactions are of high predicted confidence, whereas the interactions between miR-424-5p and CCNE1, HMGA1, PSAT1 and UCP2 are experimentally observed. 1, 2, 3, 4, 5, 6Related to cancer (italicized for ovarian cancer), cellular growth and proliferation, cell cycle, DNA replication, recombination and repair, cell-to-cell signaling and interaction, cellular development, respectively. Results were generated through the use of Ingenuity Pathway Analysis.