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Table 2 Univariate statistical analysis of disease-free survival

From: Prognostic factors for disease-specific survival in 108 patients with Hürthle cell thyroid carcinoma: a single-institution experience

Factor Subgroup Without recurrence (N = 70) With recurrence (N = 26) p-value
Gender Female 59 14 0.001
Male 11 12
Age (years) 44 or less 20 1 0.03
45 or more 50 25
Tumor diameter (cm) 0-4 44 11 0.10
4.01 and more 26 15
pT tumor stage pTx, pT1 or pT2 38 5 0.001
pT3 28 13
pT4 4 8
N stage N0 68 22 0.049
N1 2 4
M stage M0 70 26 -
M1 0 0
Tumor differentiation Well 48 13 0.06
Moderate or poor 22 13
Vascular invasion Minimal or suspected 47 16 0.47
Extensively 23 10
Capsular invasion No or minimal 34 16 0.34
Transcapsular 36 10
Thyroid surgical procedure Total or near-total thyroidectomy 55 16 0.05
Lobectomy or less 15 10
Residual tumor after surgery R0 – without residual tumor 62 15 0.005
R1 – microscopic residual tumor 5 6
R2– macroscopic residual tumor 3 5
Neck dissection No 70 22 0.005
Yes 0 4
Radioiodine ablation No 16 3 0.26
Yes 54 23
Therapy with radioiodine No 65 12 0.001
Yes 5 14
External beam radiotherapy No 62 17 0.01
Yes – neck and mediastinum 8 9
External beam radiotherapy No 64 15 0.001
Yes – any site 6 11
Chemotherapy No 66 22 0.11
Yes 4 4
Outcome Alive without disease 52 0 -
Alive with disease 0 14
Dead of disease 0 11
Dead of other causes 14 1
Lost to follow-up 4 0