Table 2 Univariate statistical analysis of disease-free survival
Factor | Subgroup | Without recurrence (N = 70) | With recurrence (N = 26) | p-value |
|---|---|---|---|---|
Gender | Female | 59 | 14 | 0.001 |
Male | 11 | 12 | ||
Age (years) | 44 or less | 20 | 1 | 0.03 |
45 or more | 50 | 25 | ||
Tumor diameter (cm) | 0-4 | 44 | 11 | 0.10 |
4.01 and more | 26 | 15 | ||
pT tumor stage | pTx, pT1 or pT2 | 38 | 5 | 0.001 |
pT3 | 28 | 13 | ||
pT4 | 4 | 8 | ||
N stage | N0 | 68 | 22 | 0.049 |
N1 | 2 | 4 | ||
M stage | M0 | 70 | 26 | - |
M1 | 0 | 0 | ||
Tumor differentiation | Well | 48 | 13 | 0.06 |
Moderate or poor | 22 | 13 | ||
Vascular invasion | Minimal or suspected | 47 | 16 | 0.47 |
Extensively | 23 | 10 | ||
Capsular invasion | No or minimal | 34 | 16 | 0.34 |
Transcapsular | 36 | 10 | ||
Thyroid surgical procedure | Total or near-total thyroidectomy | 55 | 16 | 0.05 |
Lobectomy or less | 15 | 10 | ||
Residual tumor after surgery | R0 – without residual tumor | 62 | 15 | 0.005 |
R1 – microscopic residual tumor | 5 | 6 | ||
R2– macroscopic residual tumor | 3 | 5 | ||
Neck dissection | No | 70 | 22 | 0.005 |
Yes | 0 | 4 | ||
Radioiodine ablation | No | 16 | 3 | 0.26 |
Yes | 54 | 23 | ||
Therapy with radioiodine | No | 65 | 12 | 0.001 |
Yes | 5 | 14 | ||
External beam radiotherapy | No | 62 | 17 | 0.01 |
Yes – neck and mediastinum | 8 | 9 | ||
External beam radiotherapy | No | 64 | 15 | 0.001 |
Yes – any site | 6 | 11 | ||
Chemotherapy | No | 66 | 22 | 0.11 |
Yes | 4 | 4 | ||
Outcome | Alive without disease | 52 | 0 | - |
Alive with disease | 0 | 14 | ||
Dead of disease | 0 | 11 | ||
Dead of other causes | 14 | 1 | ||
Lost to follow-up | 4 | 0 |