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Table 1 Patients’ and tumor characteristics and univariate statistical analysis of disease-specific survival

From: Prognostic factors for disease-specific survival in 108 patients with Hürthle cell thyroid carcinoma: a single-institution experience

Factor Subgroup Patients number (%) Dead of disease (N = 20) Alive or dead of other causes (N = 88) p-value
Gender Female 82 (76) 12 70 0.08
Male 26 (24) 8 18
Age (years) 44 or less 23 (21) 0 23 0.006
45 or more 85 (79) 20 65
Tumor diameter (cm) 0-4 56 (52) 2 54 0.001
4.01 and more 52 (48) 18 34
pT tumor stage pTx 1 (1) 1 0 0.001
pT1 9 (8) 0 9
pT2 35 (32) 1 34
pT3 47 (43) 9 38
pT4 16 (15) 9 7
N stage N0 100 (93) 16 84 0.04
N1 (N1a + N1b) 8 (7) 4 4
 N1a 3   
 N1b 5
M stage M0 96 (89) 11 85 0.001
M1 12 (11) 9 3
Tumor differentiation Well 66 (61) 8 58 0.03
Moderate or poor 36 + 6 (33 + 6) 12 30
Vascular invasion Minimal or suspected 66 (61) 10 56 0.26
Extensively 42 (39) 10 32
Capsular invasion No or minimal 56 (52) 8 48 0.24
Transcapsular 52 (48) 12 40
Thyroid surgical procedure Total or near-total thyroidectomy 77 (71) 8 69 0.001
Lobectomy or less 31 (29) 12 19
Residual tumor after surgery R0 – without residual tumor 80 (74) 7 73 0.001
R1 – microscopic residual tumor 19 (17) 10 9
R2– macroscopic residual tumor 9 (8) 3 6
Neck dissection No 99 (92) 15 84 0.01
Yes 9 (8) 5 4
Radioiodine ablation after surgery No 21 (20) 5 16 0.53
Yes 87 (80) 15 72
Therapy with radioiodine No 77 (71) 3 29 0.17
Yes 31 (29) 17 59
External beam radiotherapy No 85 (79) 11 74 0.004
Yes – neck and mediastinum 23 (21) 9 14
External beam radioterapy No 81 (75) 6 75 0.001
Yes – any site 27 (25) 14 13
Chemotherapy No 92 (85) 11 81 0.001
Yes 16 (15) 9 7
Recurrence No 70 (65) 0 70 -
Yes - distant 11 (10) 4 7
Yes – locoregional 12 (11) 5 7
Yes – locoregional and distant 3 (3) 2 1
Initially distant metastases 12 (11) 9 3
Outcome Alive without disease 52 (48) 0 52 -
Alive with disease 16 (15) 0 16
Dead of disease 20 (19) 20 0
Dead of other causes 15 (14) 0 15
Lost to follow-up 5 (5) 0 5
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