Figure 5
HCI2509 treatment causes tumor regression in vivo . (A) Average total body weight (g) of mice in both groups, vehicle and HCI2509 treatment, starting at implantation (day 0) through the course of the study. Data points shown represent the mean and standard deviation. (B) Quantified bioluminscence measurements of both the vehicle and HCI2509 treatment groups. Data is plotted as the geometric mean of total flux (photons/second). Daily treatment was initiated on day 7 (day 0 = implantation), such that day 14 represents the first day of imaging after the start of treatment. (C) Individual mouse images from study day 42 (day 35 of treatment). All images are on the same luminescence scale from 1.54 × 104 p/s to 8.66 × 106 p/s. Note: Animal #6 in the treatment group was sacrificed on study day 36, therefore the image is from study day 35 imaging.