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Table 4 Association of the metabolic and vascular markers expression with the clinicopathological variables in SCC samples

From: Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix

  MCT1 MCT4 CD147 GLUT1 CAIX
n Positive (%) p n Positive (%) p n Positive (%) p n Positive (%) p n Positive (%) p
Age*    0.901    0.029    0.024    0.711    0.208
 > 48 14 6 (42.9)   14 5 (35.7)   14 0 (0.0)   15 12 (80.0)   14 9 (64.3)  
 ≤ 48 20 9 (45.0)   19 14 (73.7)   18 6 (33.3)   22 16 (72.7)   19 8 (42.1)  
Tumour size*    0.644    0.600    1.000    0.624    1.000
 ≤ 2 cm 11 4 (36.4)   11 7 (63.6)   11 2 (18.2)   14 10 (71.4)   11 4 (36.4)  
 > 2 cm 6 3 (50.0)   6 5 (83.3)   6 1 (16.7)   7 6 (85.7)   6 2 (33.3)  
Clinical stage    0.634    0.138    1.000    0.307    0.335
 I 29 12 (41.4)   28 18 (64.3)   27 5 (18.5)   32 23 (71.9)   28 13 (46.4)  
 II 5 3 (60.0)   5 1 (20.0)   5 1 (20.0)   5 5 (100.0)   5 4 (80.0)  
  VEGF-A VEGF-C VEGFR-1 VEGFR-2 VEGFR-3
  n Positive (%) p n Positive (%) p n Positive (%) p n Positive (%) p n Positive (%) p
Age*    0.270    1.000    0.681    1.000    0.455
 > 48 13 11 (84.6)   14 13 (92.9)   14 2 (14.3)   14 11 (78.6)   14 3 (21.4)  
 ≤ 48 23 15 (64.2)   22 20 (90.9)   22 5 (22.7)   22 18 (81.8)   19 7 (36.8)  
Tumour size*    0.624    1.000    0.517    0.557    0.600
 ≤ 2 cm 14 10 (71.4)   13 12 (92.3)   13 3 (23.1)   13 11 (84.6)   11 4 (36.4)  
 > 2 cm 7 6 (85.7)   6 6 (100.0)   6 0 (0.0)   6 4 (66.7)   6 1 (16.7)  
Clinical stage    0.603    0.370    0.559    0.244    0.627
 I 31 23 (74.2)   31 29 (93.5)   31 7 (22.6)   31 26 (83.9)   28 8 (28.6)  
 II 5 3 (60.0)   5 4 (80.0)   5 0 (0.0)   5 3 (60.0)   5 2 (40.0)  
  1. *Mean values were used for age and tumour size cut-off.
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