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Table 4 Association of the metabolic and vascular markers expression with the clinicopathological variables in SCC samples

From: Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix

 

MCT1

MCT4

CD147

GLUT1

CAIX

n

Positive (%)

p

n

Positive (%)

p

n

Positive (%)

p

n

Positive (%)

p

n

Positive (%)

p

Age*

  

0.901

  

0.029

  

0.024

  

0.711

  

0.208

 > 48

14

6 (42.9)

 

14

5 (35.7)

 

14

0 (0.0)

 

15

12 (80.0)

 

14

9 (64.3)

 

 ≤ 48

20

9 (45.0)

 

19

14 (73.7)

 

18

6 (33.3)

 

22

16 (72.7)

 

19

8 (42.1)

 

Tumour size*

  

0.644

  

0.600

  

1.000

  

0.624

  

1.000

 ≤ 2 cm

11

4 (36.4)

 

11

7 (63.6)

 

11

2 (18.2)

 

14

10 (71.4)

 

11

4 (36.4)

 

 > 2 cm

6

3 (50.0)

 

6

5 (83.3)

 

6

1 (16.7)

 

7

6 (85.7)

 

6

2 (33.3)

 

Clinical stage

  

0.634

  

0.138

  

1.000

  

0.307

  

0.335

 I

29

12 (41.4)

 

28

18 (64.3)

 

27

5 (18.5)

 

32

23 (71.9)

 

28

13 (46.4)

 

 II

5

3 (60.0)

 

5

1 (20.0)

 

5

1 (20.0)

 

5

5 (100.0)

 

5

4 (80.0)

 
 

VEGF-A

VEGF-C

VEGFR-1

VEGFR-2

VEGFR-3

 

n

Positive (%)

p

n

Positive (%)

p

n

Positive (%)

p

n

Positive (%)

p

n

Positive (%)

p

Age*

  

0.270

  

1.000

  

0.681

  

1.000

  

0.455

 > 48

13

11 (84.6)

 

14

13 (92.9)

 

14

2 (14.3)

 

14

11 (78.6)

 

14

3 (21.4)

 

 ≤ 48

23

15 (64.2)

 

22

20 (90.9)

 

22

5 (22.7)

 

22

18 (81.8)

 

19

7 (36.8)

 

Tumour size*

  

0.624

  

1.000

  

0.517

  

0.557

  

0.600

 ≤ 2 cm

14

10 (71.4)

 

13

12 (92.3)

 

13

3 (23.1)

 

13

11 (84.6)

 

11

4 (36.4)

 

 > 2 cm

7

6 (85.7)

 

6

6 (100.0)

 

6

0 (0.0)

 

6

4 (66.7)

 

6

1 (16.7)

 

Clinical stage

  

0.603

  

0.370

  

0.559

  

0.244

  

0.627

 I

31

23 (74.2)

 

31

29 (93.5)

 

31

7 (22.6)

 

31

26 (83.9)

 

28

8 (28.6)

 

 II

5

3 (60.0)

 

5

4 (80.0)

 

5

0 (0.0)

 

5

3 (60.0)

 

5

2 (40.0)

 
  1. *Mean values were used for age and tumour size cut-off.