Figure 6From: Redox-responsive targeted gelatin nanoparticles for delivery of combination wt-p53 expressing plasmid DNA and gemcitabine in the treatment of pancreatic cancer Transfection and apoptosis induction efficiency of combination treatment. (a) mRNA expression profile for p53 and transcription factors in the apoptotic pathway. (n = 6, *p < 0.05; **p < 0.01; ***p < 0.001). (b) Western blot analysis for cleaved PARP, cleaved caspase 3 and β-actin protein expression in treated tumors. (c) TUNEL stained images of treated tumors indicating DNA fragmentation (brown stain). All images were acquired at 20× with scale bar of 50 μm.Back to article page