Table 2 ERβ1 expression levels by morphology and subtype
ERβ1 expression | Cohort 1 n = 184** | Cohort 2 n = 68 | n = 177 | ||||
|---|---|---|---|---|---|---|---|
Nucleus | Cytoplasm | Nucleus | Cytoplasm | Nucleus | Cytoplasm | ||
Molecular Subtype | |||||||
Luminal A (ERα +/ HER2 -/ Ki67 ≤ 10) | Neg/low | 31 (18.3) | 47 (25.5) | ||||
Moderate | 18 (10.7) | 3 (1.6) | |||||
High | 1 (0.6) | 0 | |||||
Luminal B (ERα +/ HER2 -/ Ki67 > 10) | Neg/low | 59 (34.9) | 76 (41.3) | ||||
Moderate | 25 (14.8) | 11 (6.0) | |||||
High | 3 (1.8) | 0 | |||||
Her2+ | Neg/low | 20 (11,8) | 24 (13.0) | ||||
Moderate | 7 (4.1) | 3 (1.6) | |||||
High | 0 | 0 | |||||
Triple Negative (ERα -/PR-/ HER2 -) | Neg/low | 1 (0.6) | 5 (2.7) | 51 (75.0) | 45 (66.2) | ||
Moderate | 4 (2.4) | 0 | 17 (25.0) | 21 (30.9) | |||
High | 0 | 0 | 0 | 2 (2.9) | |||
Histologic Subtype | |||||||
Ductal | Neg/low | 93 (50.5) | 120 (65.2) | 39 (57.4) | 34 (50.0) | 28 (15.8) | 0 |
Moderate | 42 (22.8) | 18 (9.8) | 13 (19.1) | 16 (23.5) | 79 (44.6) | 45 (25.4) | |
High | 3 (1.6) | 0 | 0 | 2 (2.9) | 36 (20.3) | 98 (55.4) | |
Lobular | Neg/low | 18 (9.8) | 26 (14.1) | 0 | 0 | 1 (0.6) | 0 |
Moderate | 9 (4.9) | 2 (1.1) | 0 | 0 | 10 (5.7) | 3 (1.7) | |
High | 1 (0.5) | 0 | 0 | 0 | 5 (2.8) | 13 (7.3) | |
Other | Neg/low | 10 (5.4) | 18 (9.8) | 12 (17.6) | 11 (16.2) | 3 (1.7) | 1 (0.6) |
Moderate | 8 (4.4) | 0 | 4 (5.9) | 5 (7.4) | 7 (4.0) | 4 (2.3) | |
High | 0 | 0 | 0 | 0 | 8 (4.5) | 13 (7.3) | |