Figure 2

Verbascoside (VB) inhibited in vivo growth of CRC tumor in a dose- and time-dependent manner. Growth of xenograft tumors in nude mice treated with different doses of VB and 5-FU at 1, 4, 7, 9, 12, and 15 days (A). Dissected tumor samples from nude mice in different treatment groups (B). Xenograft tumor volumes of mice treated with indicated doses of VB and 5-FU, respectively: 353.4 ± 124.8 mm³, 182.4 ± 54.5 mm³, 137.7 ± 37.5 mm³, 128.1 ± 40.2 mm³, and87.9 ± 62.0 mm³ (C), and xenograft tumor weights of mice treated with indicated doses of VB and 5-FU, respectively: 0.423 ± 0.150 g, 0.242 ± 0.135 g, 0.195 ± 0.057 g, 0.165 ± 0.065 g, and 0.143 ± 0.067 g (D). P < 0.05.