Figure 1
From: Nitidine chloride inhibits hepatic cancer growth via modulation of multiple signaling pathways
Effect of NC on hepatic cancer growth in vitro and in vivo . (A) Viability of HepG2, HCCLM3 or Huh7 cells was determined by the MTT assay after cells were treated with the different concentrations of NC for the indicated time periods. *P < 0.05, versus control cells. (B-E) In vivo study. After tumor development, mice were randomized into two groups (n = 10) and treated with 4.5 mg/kg of NC or saline daily by intraperitoneal injection, 6 days a week for 18 days. Tumor volume (B), tumor weight (C) and body weight (E) were measured. (D) Representative images for tumors. Data shown are averages with S.D. (error bars) from 10 individual mouse in each group. *P < 0.01, versus controls.